Goforth Harold W, Holsinger Tracey
Duke University Medical Center, and Consultation-Liaison Psychiatry Service, Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.
J ECT. 2007 Mar;23(1):23-5. doi: 10.1097/01.yct.0000263257.44539.23.
Major depressive disorder is a difficult-to-treat and recurrent debilitating disorder. All approved somatic treatments for major depression to date require a significant time lapse before demonstrating an antidepressant effect. However, emerging evidence indicates a potential role for the use of ketamine to rapidly relieve symptoms of major depression. We present a case of severe, recurrent major depressive disorder that demonstrated marked improvement within 8 hours of receiving a preoperative dose of ketamine and 1 treatment of electroconvulsive therapy with bitemporal electrode placement. This case is supportive of a role of ketamine in relieving symptoms of major depressive disorder rapidly and safely.
重度抑郁症是一种难以治疗且反复发作的使人衰弱的疾病。迄今为止，所有已获批的用于治疗重度抑郁症的躯体治疗方法在显示出抗抑郁效果之前都需要相当长的时间间隔。然而，新出现的证据表明，使用氯胺酮快速缓解重度抑郁症症状具有潜在作用。我们报告一例严重的、复发性重度抑郁症病例，该病例在接受术前剂量的氯胺酮和一次采用双侧颞部电极放置的电休克治疗后8小时内症状显著改善。该病例支持氯胺酮在快速且安全地缓解重度抑郁症症状方面的作用。
