Lee Jae, Narang Puneet, Enja Manasa, Lippmann Steven
Dr. Lee is resident physician at Hennepin-Regions Psychiatry Program, Minneapolis-St. Paul, Minnesota; Dr. Narang is staff physician and ECT psychiatrist, Regions Hospital, Minneapolis- St. Paul, Minnesota; Dr. Enja is observer physician, University of Louisville School of Medicine, Louisville, Kentucky; and Dr. Lippmann is Professor of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.
Innov Clin Neurosci. 2015 Jan-Feb;12(1-2):29-31.
Ketamine is an N-methyl-D- aspartate antagonist with rapid antidepressant effects. Research shows that ketamine has a fast onset of reduction in depressive symptoms and shows sustained remission of suicidal ideation in some patients. This article provides a brief review of the literature on the use of ketamine for depression and in acute cases of suicidality. The authors conclude that, while further investigation is needed, ketamine may be a useful treatment option for acute suicidality in emergency room settings.
氯胺酮是一种具有快速抗抑郁作用的N-甲基-D-天冬氨酸拮抗剂。研究表明，氯胺酮能快速减轻抑郁症状，且在一些患者中能持续缓解自杀意念。本文简要综述了关于氯胺酮用于治疗抑郁症及急性自杀倾向的文献。作者得出结论，虽然还需要进一步研究，但在急诊室环境中，氯胺酮可能是治疗急性自杀倾向的一种有效选择。
