偏头痛中三叉神经体感通路和导水管周围灰质的发作间期改变。
Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine.
作者信息
DaSilva Alexandre F M, Granziera Cristina, Tuch David S, Snyder Josh, Vincent Maurice, Hadjikhani Nouchine
机构信息
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
出版信息
Neuroreport. 2007 Mar 5;18(4):301-5. doi: 10.1097/WNR.0b013e32801776bb.
Abstract
Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal diffusion properties of the brains of migraineurs with aura, migraineurs without aura and matched healthy controls. Areas of lower fractional anisotropy were present in migraineurs along the thalamocortical tract. In addition, migraineurs with aura had lower fractional anisotropy in the ventral trigeminothalamic tract, and migraineurs without aura had lower fractional anisotropy in the ventrolateral periaqueductal grey matter. Our results indicate the presence of permanent interictal changes in migraineurs, pointing to an effect of migraine on the trigeminal somatosensory and modulatory pain systems.
摘要
传统上，偏头痛被认为是一种非进行性的发作性疾病，发作间期大脑无异常。我们使用扩散张量成像技术来检查有先兆偏头痛患者、无先兆偏头痛患者以及相匹配的健康对照者大脑的发作间期扩散特性。偏头痛患者沿丘脑皮质束存在分数各向异性较低的区域。此外，有先兆偏头痛患者在腹侧三叉丘脑束的分数各向异性较低，无先兆偏头痛患者在腹外侧导水管周围灰质的分数各向异性较低。我们的结果表明偏头痛患者存在永久性发作间期改变，提示偏头痛对三叉神经体感和调制性疼痛系统有影响。
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JAMA. 2006 Jul 19;296(3):283-91. doi: 10.1001/jama.296.3.283.
2
Age-related changes in prefrontal white matter measured by diffusion tensor imaging.通过扩散张量成像测量的前额叶白质的年龄相关变化。
Ann N Y Acad Sci. 2005 Dec;1064:37-49. doi: 10.1196/annals.1340.009.
3
Extensive piano practicing has regionally specific effects on white matter development.大量的钢琴练习对白质发育具有区域特异性影响。
Nat Neurosci. 2005 Sep;8(9):1148-50. doi: 10.1038/nn1516. Epub 2005 Aug 7.
4
Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study.偏头痛患者后循环区域的梗死。基于人群的MRI CAMERA研究。
Brain. 2005 Sep;128(Pt 9):2068-77. doi: 10.1093/brain/awh542. Epub 2005 Jul 8.
5
Lack of habituation of nociceptive evoked responses and pain sensitivity during migraine attack.偏头痛发作期间伤害性诱发反应和疼痛敏感性缺乏习惯化。
Clin Neurophysiol. 2005 Jun;116(6):1254-64. doi: 10.1016/j.clinph.2005.02.018. Epub 2005 Apr 2.
6
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Neurobiol Aging. 2005 Aug-Sep;26(8):1215-27. doi: 10.1016/j.neurobiolaging.2004.09.017. Epub 2004 Dec 19.
7
The International Classification of Headache Disorders, 2nd Edition (ICHD-II)--revision of criteria for 8.2 Medication-overuse headache.《国际头痛疾病分类》第二版（ICHD-II）——8.2药物过量使用性头痛的标准修订
Cephalalgia. 2005 Jun;25(6):460-5. doi: 10.1111/j.1468-2982.2005.00878.x.
8
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9
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Headache. 2005 Apr;45 Suppl 1:S25-32. doi: 10.1111/j.1526-4610.2005.4501008.x.
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