DaSilva Alexandre F M, Granziera Cristina, Tuch David S, Snyder Josh, Vincent Maurice, Hadjikhani Nouchine
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Neuroreport. 2007 Mar 5;18(4):301-5. doi: 10.1097/WNR.0b013e32801776bb.
Migraine has been traditionally considered a nonprogressive, paroxysmal disorder with no brain abnormalities between attacks. We used diffusion tensor imaging to examine interictal diffusion properties of the brains of migraineurs with aura, migraineurs without aura and matched healthy controls. Areas of lower fractional anisotropy were present in migraineurs along the thalamocortical tract. In addition, migraineurs with aura had lower fractional anisotropy in the ventral trigeminothalamic tract, and migraineurs without aura had lower fractional anisotropy in the ventrolateral periaqueductal grey matter. Our results indicate the presence of permanent interictal changes in migraineurs, pointing to an effect of migraine on the trigeminal somatosensory and modulatory pain systems.
传统上，偏头痛被认为是一种非进行性的发作性疾病，发作间期大脑无异常。我们使用扩散张量成像技术来检查有先兆偏头痛患者、无先兆偏头痛患者以及相匹配的健康对照者大脑的发作间期扩散特性。偏头痛患者沿丘脑皮质束存在分数各向异性较低的区域。此外，有先兆偏头痛患者在腹侧三叉丘脑束的分数各向异性较低，无先兆偏头痛患者在腹外侧导水管周围灰质的分数各向异性较低。我们的结果表明偏头痛患者存在永久性发作间期改变，提示偏头痛对三叉神经体感和调制性疼痛系统有影响。
