Mormann Florian, Fernández Guillén, Klaver Peter, Weber Bernd, Elger Christian E, Fell Juergen
Department of Epileptology, University of Bonn, Bonn, Germany.
Neuroreport. 2007 Mar 5;18(4):317-21. doi: 10.1097/WNR.0b013e3280287ae9.
The functional deficits associated with hippocampal sclerosis during declarative memory formation are largely unknown. In this study, we analyzed intracranial event-related potentials recorded from the medial temporal lobes of nine epilepsy patients performing a word memorization task. We used frequency-specific wavelet analysis to assess stimulus-related changes in power and intertrial phase coherence. Statistical analysis revealed a significant decrease of stimulus-induced power in the delta and theta range on the side of pathology. No significant differences in phase locking were observed. Findings indicate a reduced availability of recruitable neural assemblies not only in the hippocampus but also in the rhinal cortex during memory formation. Network functions related to the timing of neural responses to the stimulus appear to be preserved.
在陈述性记忆形成过程中，与海马硬化相关的功能缺陷在很大程度上尚不明确。在本研究中，我们分析了9名癫痫患者在进行单词记忆任务时，从内侧颞叶记录到的颅内事件相关电位。我们使用频率特异性小波分析来评估刺激相关的功率变化和试验间相位相干性。统计分析显示，病变侧在δ波和θ波范围内刺激诱发的功率显著降低。未观察到锁相方面的显著差异。研究结果表明，在记忆形成过程中，不仅海马体，而且鼻周皮质中可招募的神经集合的可用性都有所降低。与对刺激的神经反应时间相关的网络功能似乎得以保留。
