Coiro Vittorio, Casti Amos, Saccani Jotti Gloria, Rubino Pasquale, Manfredi Guido, Maffei Maria Ludovica, Di Gennaro Cristiana, Melani Andrea, Chiodera Paolo
Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy.
Neuro Endocrinol Lett. 2007 Apr;28(2):145-8.
To evaluate the effects of moderate amounts of ethanol on the GH and cortisol responses to physical exercise.
Ten normal men underwent three bicycle ergometer tests. Test were carried out in basal conditions (control test) or after drinking 0.5 or 0.75 g/kg BW ethanol. Tests lasted 15 min in all subjects; the workload was increased at 3 min intervals from time 0 until exhaustion. Non-endocrine physiological parameters (NEPP), such as heart rate, blood pressure, ventilation, frequency of breathing, tidal volume, oxygen consumption, carbon oxide production and respiratory exchange ratio were measured from time 0 until exhaustion. Serum GH and cortisol levels were evaluated in blood samples taken at 5-10 min intervals over a 50 min period from time 0.
Neither basal values, nor exercise-induced changes in NEPP were altered by ethanol drinking. Both GH and cortisol levels significantly rose during the exercise control test. The hormonal responses did not change after 0.5 g/kg BW ethanol, whereas they significantly decreased after 0.75 g/kg BW ethanol.
Modification of the GH and cortisol responses to exercise represents an "endocrine window" of the effects that even moderate ethanol drinking produces in the CNS. The data show that 0.75 g/kg BW ethanol is the minimal amount producing significant inhibitory effects on the GH and cortisol responses to physical exercise. In view of the important roles played by GH and cortisol during physical activity, even moderate ethanol drinking must be avoided before sport.
评估适量乙醇对生长激素（GH）和皮质醇对体育锻炼反应的影响。
10名正常男性进行了三次自行车测力计测试。测试在基础条件下（对照测试）或饮用0.5或0.75 g/kg体重的乙醇后进行。所有受试者的测试持续15分钟；工作量从时间0开始每隔3分钟增加，直至力竭。从时间0到力竭期间测量非内分泌生理参数（NEPP），如心率、血压、通气、呼吸频率、潮气量、耗氧量、二氧化碳产生量和呼吸交换率。在从时间0开始的50分钟内，每隔5 - 10分钟采集血样，评估血清GH和皮质醇水平。
饮酒对基础值或运动引起的NEPP变化均无影响。在运动对照测试期间，GH和皮质醇水平均显著升高。饮用0.5 g/kg体重的乙醇后，激素反应未改变，而饮用0.75 g/kg体重的乙醇后，激素反应显著降低。
生长激素和皮质醇对运动反应的改变代表了即使适量饮酒在中枢神经系统产生的影响的“内分泌窗口”。数据表明，0.75 g/kg体重的乙醇是对生长激素和皮质醇对体育锻炼反应产生显著抑制作用的最小剂量。鉴于生长激素和皮质醇在体育活动中所起的重要作用，运动前必须避免即使是适量的饮酒。
