Department of Internal Medicine and Biomedical Sciences, Via A. Gramsci 14, 43100 Parma, Italy.
Maturitas. 2010 Apr;65(4):392-5. doi: 10.1016/j.maturitas.2009.12.020. Epub 2010 Feb 1.
To evaluate whether prolonged physical activity (25 km/week running for 8 years) modifies GH decline.
The GH response to maximal exercise on bicycle-ergometer was tested in younger (26-30 years) and older (42-46 years) healthy women. Each age group included 2 subgroups of 10 sedentary and 10 runners, which were compared. The workload was increased at 3 min intervals from time 0 until exhaustion. Subjects with a low maximal capacity (as established in a preliminary test) pedalled for 3-4 min against no workload at the beginning of the test, so that exercises lasted about 15 min in all individuals.
At exhaustion, heart rate and systolic pressure were significantly higher in sedentary than in trained subjects, whereas V(O(2)max), blood glucose and plasma lactate levels were similar in all groups. Exercise induced similar GH responses in younger sedentary and exercise-trained subjects and in older exercise-trained subjects, with mean peak levels 7.5 times higher than baseline. In contrast, in older sedentary women peak GH level was only 4.4 times higher than baseline and was significantly lower than in the other groups.
These data suggest that in women prolonged physical training exerts protective effects against age-dependent decline in GH secretion.
评估长时间的体力活动（每周 25 公里跑步，持续 8 年）是否会改变 GH 的下降。
在年轻（26-30 岁）和年老（42-46 岁）健康女性中，测试了自行车测功计上最大运动对 GH 的反应。每个年龄组包括 10 名久坐不动的和 10 名跑步者的 2 个亚组，并进行了比较。工作量每隔 3 分钟从 0 时间增加到衰竭。在初步测试中确定最大能力较低的受试者在测试开始时对无负荷蹬踏 3-4 分钟，以便所有个体的运动持续约 15 分钟。
在衰竭时，静息时的心率和收缩压明显高于训练有素的受试者，而 V（O（2）max）、血糖和血浆乳酸水平在所有组中均相似。运动引起了年轻静息和运动训练受试者以及年老运动训练受试者中相似的 GH 反应，平均峰值水平比基线高 7.5 倍。相比之下，老年静息女性的 GH 峰值水平仅比基线高 4.4 倍，明显低于其他组。
这些数据表明，在女性中，长时间的体力训练对 GH 分泌随年龄下降具有保护作用。
