不同胎龄新生儿腹主动脉的内膜中层厚度。
Intima-media thickness of the abdominal aorta of neonate with different gestational ages.
作者信息
Koklu Esad, Kurtoglu Selim, Akcakus Mustafa, Yikilmaz Ali, Coskun Abdulhakim, Gunes Tamer
机构信息
Division of Neonatology, Department of Pediatrics, Erciyes University, School of Medicine, 38039 Kayseri, Turkey.
出版信息
J Clin Ultrasound. 2007 Nov-Dec;35(9):491-7. doi: 10.1002/jcu.20335.
PURPOSE
To determine aortic intima-media thickness (aIMT) values in newborns with different gestational ages and to asses the effect of antenatal steroids on aIMT.
METHODS
Two hundred forty newborns from healthy mothers had their distal abdominal aIMT measured during abdominal sonographic examination. The neonates were divided into 4 groups (60 in each group) according to gestational age: group I (25-28 weeks), group II (29-32 weeks), group III (33-37 weeks), and group IV (38-42 weeks).
RESULTS
The interobserver and intersubject intraclass correlation coefficient was 0.93 and 0.94, respectively. Mean aIMT was 0.316 mm, 0.335 mm, 0.348 mm, and 0.385 mm, respectively, in group I, II, III, and IV, increasing significantly with gestational age at birth (p < 0.0001). There was no apparent effect of antenatal steroid use on aIMT. Multivariate regression models for mean aIMT demonstrated a significant association with aortic lumen diameter (p < 0.0001).
CONCLUSION
Abdominal aIMT can be reproducibly measured in neonates and may be a useful tool for epidemiologic studies.
目的
确定不同胎龄新生儿的主动脉内膜中层厚度（aIMT）值，并评估产前使用类固醇对aIMT的影响。
方法
对240名来自健康母亲的新生儿在腹部超声检查时测量其腹部远端的aIMT。根据胎龄将新生儿分为4组（每组60名）：第一组（25 - 28周），第二组（29 - 32周），第三组（33 - 37周），第四组（38 - 42周）。
结果
观察者间和受试者间的组内相关系数分别为0.93和0.94。第一组、第二组、第三组和第四组的平均aIMT分别为0.316毫米、0.335毫米、0.348毫米和0.385毫米，随出生时胎龄增加而显著增加（p < 0.0001）。产前使用类固醇对aIMT没有明显影响。平均aIMT的多变量回归模型显示与主动脉管腔直径有显著关联（p < 0.0001）。
结论
新生儿腹部aIMT可重复测量，可能是流行病学研究的有用工具。
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