Swiss Tropical and Public Health Institute, Basel, Switzerland.
J Pediatr. 2013 May;162(5):906-11.e1-2. doi: 10.1016/j.jpeds.2012.10.060. Epub 2012 Dec 20.
To determine the association between birth weight and carotid artery intima-media thickness (CIMT), a measure of atherogenesis, in a population of 11-year-old children.
CIMT measured by high-resolution ultrasound, and birth registry data were available for 670 children of the Southern California Children's Health Study. Multivariate regression analyses were performed to investigate the association between birth weight and CIMT, with adjustment for child's health status and lifestyle, pregnancy information, and parental health.
Mean CIMT was 0.57 mm (SD 0.04). We found a nonlinear association between birth weight and CIMT, with an increase in CIMT of 0.014 mm in the fifth (P value .01) compared with the third birth weight quintile. These associations were robust in subsample analyses in children considered normal-weight by gestational age or in term-born children. No significant association with CIMT was found for the lowest quintile.
Greater birth weight was significantly associated with increased CIMT at age 11 years. No evidence for an impact of lower birth weight was found. The predictive value of childhood CIMT on future cardiovascular outcomes is largely unknown, but strong associations between childhood cardiovascular disease risk factors and adult vascular disease suggest that increased CIMT in childhood may be clinically important.
在 11 岁儿童人群中，确定出生体重与颈动脉内膜中层厚度（CIMT）的关系，CIMT 是动脉粥样硬化形成的一个衡量指标。
南加州儿童健康研究中的 670 名儿童可提供 CIMT 的高分辨率超声测量值和出生登记数据。采用多元回归分析来调查出生体重与 CIMT 之间的关系，并对儿童的健康状况和生活方式、妊娠信息以及父母健康进行调整。
平均 CIMT 为 0.57 毫米（标准差 0.04）。我们发现出生体重与 CIMT 之间存在非线性关系，与第五个（P 值<.01）相比，第三个出生体重五分位组的 CIMT 增加了 0.014 毫米。这些关联在按胎龄或足月出生的正常体重儿童的亚组分析中是稳健的。在最低五分位组中，与 CIMT 无显著关联。
较大的出生体重与 11 岁时 CIMT 增加显著相关。没有证据表明较低的出生体重有影响。儿童 CIMT 对未来心血管结局的预测价值尚不清楚，但儿童期心血管疾病危险因素与成人血管疾病之间存在强烈关联，这表明儿童期 CIMT 增加可能具有临床重要性。
