Golshayan D, Mathieu C, Burnier M
Service de néphrologie et consultation d'hypertension, CHUV, 1011 Lausanne.
Rev Med Suisse. 2007 Mar 7;3(101):588, 590-2, 594-5.
Pregnancy has generally been regarded as very high risk in women with chronic renal insufficiency. In this review, we describe the physiologic changes in systemic and renal haemodynamics during pregnancy, as well as the nature and severity of possible maternal and foetal complications in the setting of underlying renal disease. The risks are proportional to the degree of functional renal impairment, the presence or not of proteinuria and/or arterial hypertension at the time of conception, and are related to the type of underlying nephropathy or systemic disease in the mother. Furthermore, if the renal disease has been diagnosed before pregnancy, a better planning of the moment of conception, as well as a tight follow-up, allow for a better maternal and obstetrical outcome.
妊娠通常被认为对于患有慢性肾功能不全的女性具有极高风险。在本综述中，我们描述了妊娠期间全身和肾脏血流动力学的生理变化，以及在存在基础肾脏疾病的情况下可能出现的母婴并发症的性质和严重程度。风险与功能性肾功能损害的程度、受孕时是否存在蛋白尿和/或动脉高血压成正比，并且与母亲潜在的肾病或全身性疾病的类型有关。此外，如果在妊娠前已诊断出肾脏疾病，更好地规划受孕时间以及密切随访，可实现更好的母婴和产科结局。
