McPhie J L, Short L T
Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):387-91.
Hepatic collagen synthesis was studied during progressive fibrosis induced by carbon tetrachloride in male Sprague-Dawley rats by determination of prolyl hydroxylase activity and hydrocyproline levels along with morphological assessment of fibrosis. Cirrhosis was present after approximately 4 weeks treatment. Prolyl hydroxylase activity was increased significantly before fibrosis was apparent histologically or by hydroxyproline levels. The significance of this finding is discussed.
通过测定脯氨酰羟化酶活性和羟脯氨酸水平，并结合纤维化的形态学评估，研究了四氯化碳诱导雄性斯普拉格-道利大鼠进行性纤维化过程中的肝胶原合成。治疗约4周后出现肝硬化。在组织学上纤维化明显或羟脯氨酸水平升高之前，脯氨酰羟化酶活性就显著增加。讨论了这一发现的意义。
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