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巨大细胞瘤并发长骨佩吉特病

Giant cell tumor complicating Paget disease of long bone.

作者信息

Hoch Benjamin, Hermann George, Klein Michael J, Abdelwahab Ibrahim Fikry, Springfield Dempsey

机构信息

Department of Pathology, Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1194, New York, NY 07422, USA.

出版信息

Skeletal Radiol. 2007 Oct;36(10):973-8. doi: 10.1007/s00256-007-0310-x. Epub 2007 Apr 14.

Abstract

Giant cell tumor (GCT) is a rare complication of Paget disease of bone. It usually occurs in the skull or pelvic bones of patients with long-standing polyostotic disease. This report describes a 62-year-old patient who presented with monostotic Paget disease of the distal femur complicated by GCT. He had a 2-year history of discomfort and pain in his left knee. Conventional plain films and MRI demonstrated the characteristic bone changes of Paget disease and an associated lytic lesion involving the epiphyseal and metaphyseal regions of the distal femur. A diagnostic curettage showed the characteristic histopathologic features of Paget disease and GCT. There was no evidence of malignancy. The clinicopathologic features of this rare lesion are described and correlated with a review of the literature.

摘要

骨巨细胞瘤(GCT)是骨佩吉特病的一种罕见并发症。它通常发生在患有长期多骨型疾病患者的颅骨或骨盆骨中。本报告描述了一名62岁的患者,其表现为股骨远端单骨型佩吉特病并发骨巨细胞瘤。他有2年左膝不适和疼痛的病史。传统的X线平片和磁共振成像(MRI)显示了佩吉特病的典型骨质改变以及一个累及股骨远端骨骺和干骺端区域的溶骨性病变。诊断性刮除术显示了佩吉特病和骨巨细胞瘤的典型组织病理学特征。没有恶性肿瘤的证据。本文描述了这种罕见病变的临床病理特征,并与文献复习结果进行了相关性分析。

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