干扰素α-2a与鬼臼树脂治疗原发性尖锐湿疣的比较。尖锐湿疣国际协作研究组
A comparison of interferon alfa-2a and podophyllin in the treatment of primary condylomata acuminata. The Condylomata International Collaborative Study Group.
出版信息
Genitourin Med. 1991 Oct;67(5):394-9. doi: 10.1136/sti.67.5.394.
OBJECTIVES
to compare the response to treatment and recurrence rate of condylomata accuminata using subcutaneous injection of interferon alfa 2a 1.5 million units three times weekly for four weeks, or podophyllin resin 25% applied to lesions twice weekly for up to six weeks.
DESIGN
Randomised open study.
SETTING
Multicentre European study in genitourinary medicine, dermatovenereology, and gynaecology departments.
PATIENTS
87 males and 67 females with condylomata acuminata for less than six months and no history of previous treatment.
MAIN OUTCOME MEASURES
Complete clearance of lesions and evidence of recurrence at three months and nine months after treatment commenced.
RESULTS
A complete response was achieved at three months in 15 of 64 (23%) in the interferon treated group, and 31 of 69 (45%) in the podophyllin treated group (p = 0.003). At nine months 10 of 13 patients in the interferon group and 22 of 30 patients in the podophyllin group remained completely clear of lesions.
目的
比较采用皮下注射干扰素α2a 150万单位、每周3次、共4周，或25%鬼臼树脂每周2次涂抹于疣体、最长6周的治疗方法，尖锐湿疣的治疗反应及复发率。
设计
随机开放研究。
地点
欧洲多中心泌尿生殖医学、皮肤性病学和妇科科室研究。
患者
87例男性和67例女性尖锐湿疣患者，病程少于6个月，且既往无治疗史。
主要观察指标
治疗开始后3个月和9个月时疣体完全清除情况及复发证据。
结果
干扰素治疗组64例中的15例（23%）在3个月时获得完全缓解，鬼臼树脂治疗组69例中的31例（45%）在3个月时获得完全缓解（p = 0.003）。9个月时，干扰素组13例患者中的10例和鬼臼树脂组30例患者中的22例疣体仍完全清除。
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