Schneider A, Papendick U, Gissmann L, De Villiers E M
Labor für Gynäkologische Zytologie und Histologie, Universitäts-Frauenklinik, Ulm, FRG.
Int J Cancer. 1987 Nov 15;40(5):610-4. doi: 10.1002/ijc.2910400506.
Eighteen women and 6 of their male sexual partners with lower genital tract infections caused by various human papillomavirus (HPV) types were treated with systemic or topical interferon (IFN) application. All patients with vulvar or penile lesions had a history of podophyllin or surgical treatment. In the female group, 9 patients showed complete response, 8 patients partial response and 1 patient no response. In the male patients complete response was seen in all patients. The response rate appears to depend on the HPV type present. Women with an HPV 16/18 infection showed a lower response rate to IFN treatment (complete response in 5 out of 14 patients), whereas lesions caused by HPV 6(11) showed complete response in all 4 cases. During follow-up examinations (mean 7.5 months) no recurrence of disease was observed. Systemic treatment showed tolerable and temporary side-effects. Topical treatment yielded identical efficacy and no side-effects.
18名患有由多种人乳头瘤病毒（HPV）类型引起的下生殖道感染的女性及其6名男性性伴侣接受了全身或局部应用干扰素（IFN）治疗。所有患有外阴或阴茎病变的患者都有过鬼臼树脂或手术治疗史。在女性组中，9例患者完全缓解，8例部分缓解，1例无反应。在男性患者中，所有患者均完全缓解。缓解率似乎取决于所存在的HPV类型。感染HPV 16/18的女性对IFN治疗的缓解率较低（14例患者中有5例完全缓解），而由HPV 6(11)引起的病变在所有4例中均完全缓解。在随访检查期间（平均7.5个月）未观察到疾病复发。全身治疗显示出可耐受的暂时副作用。局部治疗产生相同的疗效且无副作用。
