Mansano Roy Z, Beall Marie H, Ross Michael G
Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, California 90509, USA.
J Matern Fetal Neonatal Med. 2007 Jan;20(1):47-52. doi: 10.1080/14767050601055279.
The addition of ST waveform analysis (STAN, Neoventa, Sweden) to fetal heart rate (FHR) tracings has been demonstrated to improve fetal outcome and reduce operative delivery rates, though the actual level of fetal acidosis at which STAN indicates intervention has not been assessed. We sought to determine if FHR ST segment analysis recommends intervention at appropriate levels of fetal acidosis.
FHR tracings of 10 acidotic and 10 non-acidotic infants with FHR tracings having a minimum of one STAN flag were retrospectively analyzed. Fetal base deficit (BD) was calculated by interpolation throughout the FHR tracing and STAN 'action' and 'ignore' flags assigned a fetal BD value. A secondary analysis was performed with a revised interpretation of FHR reassuring status.
The mean (+/-SD) BD of the first STAN action was significantly greater than the first 'ignore' (4.0+/-2.1 vs. 3.0+/-0.8 mmol/L, p<0.05). Clarified STAN criteria for reassuring vs. non-reassuring FHR resulted in a first action BD of 6.0+/-2.0 mmol/L with 90% sensitivity and 100% specificity for prediction of fetal acidosis.
The STAN monitor discriminates increasing levels of fetal BD. With clarification of the criteria for reassuring FHR, the calculated BDs of action flags are an appropriate threshold for emergent intervention, successfully predict acidotic fetuses, and avoid unnecessary intervention.
尽管尚未评估ST波形分析(STAN,瑞典Neoventa公司)应用于胎儿心率(FHR)描记图时提示干预的实际胎儿酸中毒水平,但已证实其可改善胎儿结局并降低手术分娩率。我们试图确定FHR ST段分析是否能在适当的胎儿酸中毒水平时推荐进行干预。
回顾性分析10例酸中毒和10例非酸中毒婴儿的FHR描记图,这些描记图至少有一个STAN标记。通过对整个FHR描记图进行插值计算胎儿碱缺失(BD),并为STAN的“行动”和“忽略”标记赋予胎儿BD值。对FHR正常状态的修订解释进行了二次分析。
首次STAN行动时的平均(±标准差)BD显著高于首次“忽略”时(4.0±2.1 vs. 3.0±0.8 mmol/L,p<0.05)。明确的STAN关于FHR正常与异常的标准导致首次行动时的BD为6.0±2.0 mmol/L,对胎儿酸中毒预测的敏感性为90%,特异性为100%。
STAN监护仪可区分胎儿BD水平的升高。随着FHR正常标准的明确,行动标记计算出的BD是紧急干预的合适阈值,能成功预测酸中毒胎儿并避免不必要的干预。