Guven Emine Seda Guvendag, Ozturk Nezahat, Deveci Sema, Hizli Deniz, Kandemir Omer, Dilbaz Serdar
Health Ministry, Etlik Maternity and Women's Health Teaching Hospital, Ankara, Turkey.
J Matern Fetal Neonatal Med. 2007 Feb;20(2):175-81. doi: 10.1080/14767050601134991.
To evaluate cases of partial hydatidiform mole coexisting with a live fetus, including an observation of our own, and to discuss the proper antenatal management of women wishing to continue with a partial molar pregnancy.
A PubMed search was then undertaken, extending over the time period from 1975 to 2006, using the keywords 'partial hydratidiform mole', 'hydatidiform mole' and 'coexisting fetus'.
At 16 weeks of gestation, an ultrasonographic examination revealed a normal fetus with an extremely large, multicystic placenta. The woman was informed of future risks but wished to continue with the pregnancy. The pregnancy progressed until 28 weeks without any complication but ended spontaneously with a vaginal delivery; the fetus had died in utero. Pathologic examination of the placenta revealed areas of hydropic degeneration and necrosis. Including our own observation, 17 cases of partial hydatidiform mole associated with a fetus of normal karyotype have been documented.
Although the rate of adverse perinatal outcome is high, we still believe that if amniocentesis or fetal blood sampling reveals a normal karyotype, then continuing the affected pregnancy with close follow-up in tertiary centers is a feasible choice.
评估部分性葡萄胎合并活胎的病例，包括我们自己观察的1例，并讨论希望继续妊娠的部分性葡萄胎孕妇合适的产前管理。
随后进行了一项PubMed检索，检索时间跨度为1975年至2006年，使用关键词“部分性葡萄胎”、“葡萄胎”和“合并胎儿”。
妊娠16周时，超声检查发现一个正常胎儿伴有一个极大的多囊性胎盘。该孕妇被告知未来的风险，但希望继续妊娠。妊娠进展至28周无任何并发症，但最终自然分娩；胎儿已死于宫内。胎盘病理检查显示有水肿变性和坏死区域。包括我们自己的观察在内，已有17例部分性葡萄胎合并核型正常胎儿的病例被记录。
尽管围产期不良结局的发生率很高，但我们仍然认为，如果羊膜穿刺术或胎儿血样检查显示核型正常，那么在三级中心密切随访下继续受影响的妊娠是一个可行的选择。
