Zalud Ivica, Shaha Steven
Department of Obstetrics and Gynecology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96826, USA.
J Matern Fetal Neonatal Med. 2007 Apr;20(4):299-305. doi: 10.1080/14767050601158206.
To define normative data with three-dimensional (3D) Doppler ultrasound in the second trimester spiral arteries and placental volume blood flow.
An entry criterion was a documented singleton pregnancy at 14-25 weeks with normal outcome. Each patient had a 3D power Doppler exam. Automatic volume acquisition of the placental and spiral arteries blood flow was obtained. We calculated vascularization index (VI), flow index (FI) and vascularization flow index (VFI). The patients were further divided into subgroups based on two gestational week intervals. The outcome measure was normal pregnancy outcome.
One hundred ninety-nine patients were included in this study. Placental and spiral arteries vascular indices slowly increased indicating progressive development of vascular network and increase in the volume blood flow. The range for placental VI was 11.43-14.63, FI was 37.44-40 and VFI was 4.77-6.06. The range for spiral arteries VI was 19-20.91, FI was 39.66-41.1 and VFI was 8.49-8.92. The mean gestational age at delivery was 38.18 weeks.
We defined normal 3D power Doppler vascular indices in pregnancies between 14 and 25 weeks of singleton gestation. The study indicated that placental and spiral arteries volume blood flow increased with the advancement of gestational age.
利用三维（3D）多普勒超声确定孕中期螺旋动脉和胎盘容积血流的正常数据。
纳入标准为记录在案的单胎妊娠，孕龄14 - 25周，结局正常。每位患者均接受3D能量多普勒检查，自动采集胎盘和螺旋动脉的血流情况，计算血管化指数（VI）、血流指数（FI）和血管化血流指数（VFI）。根据两个孕周间隔将患者进一步分为亚组，结局指标为正常妊娠结局。
本研究共纳入199例患者。胎盘和螺旋动脉的血管指数缓慢上升，表明血管网络逐渐发育，容积血流增加。胎盘VI的范围为11.43 - 14.63，FI为37.44 - 40，VFI为4.77 - 6.06。螺旋动脉VI的范围为19 - 20.91，FI为39.66 - 41.1，VFI为8.49 - 8.92。平均分娩孕周为38.18周。
我们确定了单胎妊娠14至25周期间正常的3D能量多普勒血管指数。该研究表明，胎盘和螺旋动脉的容积血流随孕周增加而增加。
