Skarda David E, Taylor Jodie H, Chipman Jeffrey G, Larson Matthew, Baker Jason V, Schacker Timothy W, Beilman Gregory J
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Surg Infect (Larchmt). 2007 Apr;8(2):173-8. doi: 10.1089/sur.2006.020.
The incidence of postoperative complications in human immunodeficiency virus (HIV)-infected patients remains controversial. Published data suggest that these patients are at higher risk for postoperative surgical site infections (SSIs) than are uninfected patients if the site is contaminated. To determine the incidence of postoperative SSI in HIV-infected patients undergoing aseptic surgery at uncontaminated sites, we performed a prospective case series analysis. We hypothesized that the rate of postoperative SSI would be low for this aseptic procedure, irrespective of CD4(+) lymphocyte counts. Additionally, we monitored the rates of other complications, namely, hematoma, dorsal vein thrombosis, epididymitis, lymphocele, and suture extrusion.
From May 1, 2000, through January 31, 2006, we performed 137 sterile inguinal lymph node biopsies in 44 HIV-infected patients as part of a funded study evaluating the role of peripheral lymphatic tissue in the pathophysiology of HIV infection. Postoperatively, we followed all patients for a minimum of 30 days.
Postoperatively, we noted one instance each (0.7%) of infection, dorsal vein thrombosis with epididymitis (0.7%), and lymphocele and two cases each (1.4%) of hematoma and suture extrusion. The CD4(+) count at the time of biopsy did not correlate with postoperative complications.
Inguinal lymph node biopsy in HIV-infected patients is safe, irrespective of CD4(+) lymphocyte count.
人类免疫缺陷病毒（HIV）感染患者术后并发症的发生率仍存在争议。已发表的数据表明，如果手术部位受到污染，这些患者术后手术部位感染（SSI）的风险高于未感染患者。为了确定在未受污染部位接受无菌手术的HIV感染患者术后SSI的发生率，我们进行了一项前瞻性病例系列分析。我们假设，无论CD4(+)淋巴细胞计数如何，这种无菌手术的术后SSI发生率都会很低。此外，我们还监测了其他并发症的发生率，即血肿、背静脉血栓形成、附睾炎、淋巴囊肿和缝线外露。
从2000年5月1日至2006年1月31日，作为一项评估外周淋巴组织在HIV感染病理生理学中作用的资助研究的一部分，我们对44例HIV感染患者进行了137例无菌腹股沟淋巴结活检。术后，我们对所有患者进行了至少30天的随访。
术后，我们记录到感染、伴有附睾炎的背静脉血栓形成（各1例，0.7%）、淋巴囊肿各1例，血肿和缝线外露各2例（各1.4%）。活检时的CD4(+)计数与术后并发症无关。
HIV感染患者的腹股沟淋巴结活检是安全的，无论CD4(+)淋巴细胞计数如何。
