Kim Dennis, Baraniuk James N
Division of Rheumatology, Immunology and Allergy, Room B105, Lower Level Kober-Cogen Building, Georgetown University, 3800 Reservoir Road, NW, Washington, DC 20007-2197, USA.
Curr Allergy Asthma Rep. 2007 May;7(2):85-92. doi: 10.1007/s11882-007-0004-4.
Ion channels are a complex set of proteins having many important physiologic and potentially pathologic roles. The flow of ions through these channels and the subsequent cellular depolarization can trigger complex mechanisms such as cardiac rhythm, hormone secretion, and numerous sensory experiences. The transient receptor potential (TRP) channels are an important means for multiple organ systems to interact with their environment. The various TRP channel subfamilies respond to voltage or to ligands such as G-protein coupled receptors. Their ability to sense temperature, pain, stretch, and osmolarity among others enables them to mediate responses such as smooth muscle contraction, cough, or sensation of pain.
离子通道是一组复杂的蛋白质，具有许多重要的生理和潜在病理作用。离子通过这些通道的流动以及随后的细胞去极化可触发复杂的机制，如心律、激素分泌和众多感觉体验。瞬时受体电位（TRP）通道是多个器官系统与周围环境相互作用的重要方式。各种TRP通道亚家族对电压或配体（如G蛋白偶联受体）作出反应。它们感知温度、疼痛、拉伸和渗透压等的能力使它们能够介导诸如平滑肌收缩、咳嗽或疼痛感觉等反应。
