Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA.
Pharmacol Rev. 2010 Sep;62(3):381-404. doi: 10.1124/pr.110.002725.
Transient receptor potential (TRP) channels are a large family of ion channel proteins, surpassed in number in mammals only by voltage-gated potassium channels. TRP channels are activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors. They respond to environmental stimuli such as temperature, pH, osmolarity, pheromones, taste, and plant compounds, and intracellular stimuli such as Ca(2+) and phosphatidylinositol signal transduction pathways. However, it is still largely unknown how TRP channels are activated in vivo. Despite the uncertainties, emerging evidence using TRP channel knockout mice indicates that these channels have broad function in physiology. Here we review the recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels.
瞬时受体电位 (TRP) 通道是一大类离子通道蛋白，其数量在哺乳动物中仅次于电压门控钾通道。TRP 通道通过显著不同的机制被激活和调节，使它们成为细胞传感器的合适候选者。它们对外界刺激如温度、pH 值、渗透压、信息素、味觉和植物化合物以及细胞内刺激如 Ca(2+) 和磷脂酰肌醇信号转导途径作出反应。然而，TRP 通道在体内是如何被激活的，目前还知之甚少。尽管存在不确定性，但使用 TRP 通道敲除小鼠的新出现证据表明，这些通道在生理学中具有广泛的功能。在这里，我们综述了哺乳动物 TRP 通道的生理学、药理学和病理生理学功能的最新进展。
