阿莫西林、克林霉素、多西环素、甲硝唑和莫西沙星对口腔放线菌的体外活性
In vitro activity of amoxicillin, clindamycin, doxycycline, metronidazole, and moxifloxacin against oral Actinomyces.
作者信息
LeCorn Demetrick W, Vertucci Frank J, Rojas Maria F, Progulske-Fox Ann, Bélanger Myriam
机构信息
Department of Endodontics, College of Dentistry, and Center for Molecular Microbiology, University of Florida, Gainesville, FL 32610-0424, USA.
出版信息
J Endod. 2007 May;33(5):557-60. doi: 10.1016/j.joen.2007.02.002. Epub 2007 Mar 26.
Actinomyces spp have been increasingly associated with endodontic infections. However, the antimicrobial susceptibility of this genus has not been studied extensively. The objective of this study was to determine the susceptibility of oral isolates of Actinomyces naeslundii, Actinomyces gerencseriae, Actinomyces israelii, Actinomyces viscosus, and Actinomyces odontolyticus to amoxicillin, clindamycin, doxycycline, metronidazole, and moxifloxacin using in vitro assays. The minimum inhibitory concentration (MIC) of each bacterial isolate was determined by using E-test strips (AB Biodisk, Solna, Sweden). The MIC(90) was 0.19 microg/mL for amoxicillin, 0.25 microg/mL for doxycycline, 0.50 microg/mL for moxifloxacin, and 1.00 microg/mL for clindamycin. However, metronidazole was not active against any of the Actinomyces spp tested (MIC(90)>256 microg/mL).
放线菌属已越来越多地与牙髓感染相关联。然而，该属的抗菌药敏性尚未得到广泛研究。本研究的目的是通过体外试验确定内氏放线菌、杰氏放线菌、衣氏放线菌、黏性放线菌和溶牙放线菌的口腔分离株对阿莫西林、克林霉素、多西环素、甲硝唑和莫西沙星的药敏性。使用E-test试纸条（AB Biodisk，瑞典索尔纳）测定每种细菌分离株的最低抑菌浓度（MIC）。阿莫西林的MIC(90)为0.19μg/mL，多西环素为0.25μg/mL，莫西沙星为0.50μg/mL，克林霉素为1.00μg/mL。然而，甲硝唑对所测试的任何放线菌属均无活性（MIC(90)>256μg/mL）。
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