González-Polo Rosa A, Niso-Santano Mireia, Ortíz-Ortíz Miguel A, Gómez-Martín Ana, Morán José M, García-Rubio Lourdes, Francisco-Morcillo Javier, Zaragoza Concepción, Soler Germán, Fuentes José M
CIBER de Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, EU Enfermería y TO, Universidad de Extremadura, Cáceres, Spain.
Autophagy. 2007 Jul-Aug;3(4):366-7. doi: 10.4161/auto.4194. Epub 2007 Jul 26.
Paraquat (PQ) (1, 1'-dimethyl-4, 4'-bipyridinium dichloride), a widely used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease (PD). In neurons from patients with PD display characteristics of autophagy, a degradative mechanism involved in the recycling and turnover of cytoplasmic constituents from eukaryotic cells. Low concentrations of paraquat have been recently found to induce autophagy in human neuroblastoma cells, and ultimately the neurons succumb to apoptotic death. Whereas caspase inhibition retarded cell death, autophagy inhibition accelerated the apoptotic cell death induced by paraquat. These findings suggest a relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat and open a new line of investigation to advance our knowledge regarding the origin of PD.
百草枯（PQ）（1,1'-二甲基-4,4'-联吡啶二氯化物）是一种广泛使用的除草剂，已被认为是帕金森病（PD）发病的潜在病因。帕金森病患者的神经元表现出自噬特征，自噬是一种参与真核细胞细胞质成分循环和周转的降解机制。最近发现低浓度的百草枯可诱导人神经母细胞瘤细胞发生自噬，最终神经元会死于凋亡。而半胱天冬酶抑制可延缓细胞死亡，自噬抑制则加速了百草枯诱导的凋亡细胞死亡。这些发现表明，在用百草枯处理的人神经母细胞瘤细胞中，自噬与凋亡细胞死亡之间存在关联，并开辟了一条新的研究途径，以增进我们对帕金森病起源的认识。
