Su Wei-Wen, Ho Wan-Jing, Cheng Shih-Tsung, Chang Shirley H L, Wu Shiu-Chen
Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan.
J Glaucoma. 2007 May;16(3):320-3. doi: 10.1097/IJG.0b013e3180391a83.
To determine the systemic high-sensitivity C-reactive protein (hsCRP) level in patients with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG).
With the exclusion of patients with cardiovascular and other systemic diseases, 40 patients with NTG, 40 with POAG, and 40 normal controls were enrolled in this study. Each patient underwent blood sampling for hsCRP, biochemistry, and lipid profile analysis.
Each group had similar demographic parameters including the age, sex, body mass index, heart rate, and blood pressure. There was no statistically significant difference in the hsCRP and biochemistry results between the 3 groups. The lipid profile exhibited a mild elevation in the patients with POAG.
Our data revealed no difference in the hsCRP level between NTG, POAG, and normal controls after exclusion of patients with cardiovascular and other systemic diseases. Systemic vascular inflammation may not be a major cause in the pathogenesis of glaucoma in those without histories of cardiovascular diseases.
测定正常眼压性青光眼（NTG）和原发性开角型青光眼（POAG）患者的全身高敏C反应蛋白（hsCRP）水平。
排除患有心血管疾病和其他全身性疾病的患者，本研究纳入了40例NTG患者、40例POAG患者和40例正常对照者。每位患者均接受血液采样以进行hsCRP、生化和血脂分析。
每组的人口统计学参数相似，包括年龄、性别、体重指数、心率和血压。三组之间的hsCRP和生化结果无统计学显著差异。POAG患者的血脂水平有轻度升高。
我们的数据显示，在排除患有心血管疾病和其他全身性疾病的患者后，NTG、POAG和正常对照者之间的hsCRP水平无差异。在没有心血管疾病病史的人群中，全身性血管炎症可能不是青光眼发病机制的主要原因。
