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Eur Cytokine Netw. 2006 Mar;17(1):13-8.
2
Inhibition of atherogenesis in LDLR knockout mice by systemic delivery of adeno-associated virus type 2-hIL-10.通过全身递送2型腺相关病毒-人白细胞介素-10抑制低密度脂蛋白受体基因敲除小鼠的动脉粥样硬化形成
Atherosclerosis. 2006 Sep;188(1):19-27. doi: 10.1016/j.atherosclerosis.2005.10.029. Epub 2005 Nov 21.
3
Cytokines and cardiovascular disease.
J Leukoc Biol. 2005 Oct;78(4):805-18. doi: 10.1189/jlb.0405182. Epub 2005 Jul 8.
4
Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk.白细胞介素-10启动子多态性与降低乳腺癌风险相关。
Breast Cancer Res Treat. 2005 Mar;90(2):113-5. doi: 10.1007/s10549-004-3607-7.
5
Heritability estimates of innate immunity: an extended twin study.先天性免疫的遗传力估计：一项扩展的双胞胎研究。
Genes Immun. 2005 Mar;6(2):167-70. doi: 10.1038/sj.gene.6364162.
6
Role of the interleukin-6 -174 G>C gene polymorphism in retinal artery occlusion.白细胞介素-6 -174 G>C基因多态性在视网膜动脉阻塞中的作用
Stroke. 2005 Feb;36(2):249-52. doi: 10.1161/01.STR.0000151329.84830.37. Epub 2004 Dec 16.
7
Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice.腺相关病毒载体介导的白细胞介素-10基因转移可抑制载脂蛋白E缺陷小鼠的动脉粥样硬化。
Gene Ther. 2004 Dec;11(24):1772-9. doi: 10.1038/sj.gt.3302348.
8
Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout mice.白细胞源性白细胞介素10是低密度脂蛋白受体敲除小鼠抗动脉粥样硬化所必需的。
Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1474-8. doi: 10.1161/01.ATV.0000134378.86443.cd. Epub 2004 Jun 3.
9
Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice.白细胞介素-10 cDNA 的肌肉内基因转移可减轻载脂蛋白 E 基因敲除小鼠的动脉粥样硬化。
Atherosclerosis. 2004 Jan;172(1):21-9. doi: 10.1016/j.atherosclerosis.2003.08.032.
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Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.白细胞介素-10启动子多态性与造血细胞移植后移植物抗宿主病及生存的关系。
N Engl J Med. 2003 Dec 4;349(23):2201-10. doi: 10.1056/NEJMoa022060.

单倍型标签白细胞介素-10启动子多态性与视网膜动脉阻塞风险降低相关。

Haplotype-tagging interleukin-10 promoter polymorphism is associated with reduced risk of retinal artery occlusion.

作者信息

Weger Martin, Steinbrugger Iris, El-Shabrawi Yosuf, Wegscheider Beate Julia, Weger Wolfgang, Renner Wilfried, Schmut Otto, Haas Anton

机构信息

Department of Ophthalmology, Medical University of Graz, Austria.

出版信息

Mol Vis. 2007 Apr 4;13:549-52.

PMID:17438520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2652019/
Abstract

PURPOSE

Pro- and anti-inflammatory cytokines, including interleukin 10 (IL-10), play an essential role in atherogenesis. Increased IL-10 production has been found among carriers of the IL10 [TCATA] haplotype, which is formed by five polymorphisms at position -3575, -2763, -1082, -819, and -592 in the promoter region of the IL10 gene. Due to linkage disequilibrium, the presence of the [TCATA] haplotype can be unequivocally determined by analysis of the IL10-592C>A polymorphism. The purpose of the present study was to investigate a hypothesized association between the haplotype-tagging IL10 -592C>A polymorphism and the presence of retinal artery occlusion (RAO).

METHODS

The present case-control study was comprised of 194 patients with RAO and 257 normal control subjects. Genotypes of the IL10 -592C>A polymorphism were determined by fluorogenic exonuclease (TaqMan) assay.

RESULTS

Carriers of the IL10 -592A-allele, indicating the presence of the IL10 [TCATA] haplotype, were found significantly more often in controls than among patients with RAO (48.6% versus 36.1%; p=0.008). In a logistic regression analysis after adjusting for age, sex, arterial hypertension, diabetes mellitus, hypercholesterolemia, and smoking habits, carriage of the IL10 -592A-allele was associated with an odds ratio of 0.65 (95% CI: 0.44-0.97) for RAO.

CONCLUSIONS

Our data suggest that the IL10 [TCATA] haplotype, identified by the presence of the IL10 -592A-allele, may exert a protective effect against RAO.

摘要

目的

促炎和抗炎细胞因子，包括白细胞介素10（IL-10），在动脉粥样硬化形成中起重要作用。在IL10 [TCATA]单倍型携带者中发现IL-10产生增加，该单倍型由IL10基因启动子区域-3575、-2763、-1082、-819和-592位置的五个多态性形成。由于连锁不平衡，[TCATA]单倍型的存在可通过分析IL10 -592C>A多态性明确确定。本研究的目的是调查单倍型标签IL10 -592C>A多态性与视网膜动脉阻塞（RAO）存在之间的假设关联。

方法

本病例对照研究包括194例RAO患者和257例正常对照受试者。通过荧光外切酶（TaqMan）测定法确定IL10 -592C>A多态性的基因型。

结果

在对照组中发现携带IL10 -592A等位基因（表明存在IL10 [TCATA]单倍型）的情况明显多于RAO患者（48.6%对36.1%；p=0.008）。在对年龄、性别、动脉高血压、糖尿病、高胆固醇血症和吸烟习惯进行调整后的逻辑回归分析中，携带IL10 -592A等位基因与RAO的比值比为0.65（95%可信区间：0.44 - 0.97）相关。

结论

我们的数据表明，由IL10 -592A等位基因的存在所确定的IL10 [TCATA]单倍型可能对RAO具有保护作用。