Kraft Stefan, Kinet Jean-Pierre
Laboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine 945, 71 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA.
Nat Rev Immunol. 2007 May;7(5):365-78. doi: 10.1038/nri2072.
The high-affinity Fc receptor for IgE (FcepsilonRI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of FcepsilonRI. The first area relates to FcepsilonRI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by FcepsilonRI; and the third area relates to the accumulated evidence for the tight control of FcepsilonRI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.
IgE高亲和力Fc受体（FcepsilonRI）是一种多聚体免疫受体，是IgE介导的过敏反应的关键结构。近年来，FcepsilonRI研究的几个重要领域取得了进展。第一个领域涉及FcepsilonRI介导的与抗原无关的生物学反应。第二个领域包括由FcepsilonRI激活的不同信号通路的生物学相关性；第三个领域涉及通过广泛的抑制机制对FcepsilonRI信号进行严格控制的累积证据，这些机制正在发展成为有前景的治疗方法。
