Davidson Victor L
Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Biochemistry. 2007 May 8;46(18):5283-92. doi: 10.1021/bi700468t. Epub 2007 Apr 17.
Recent advances in enzymology, structural biology, and protein chemistry have extended the scope of the field of cofactor-dependent enzyme catalysis. It has been documented that catalytic and redox-active prosthetic groups may be derived from post-translational modification of amino acid residues of proteins. These protein-derived cofactors typically arise from the oxygenation of aromatic residues, covalent cross-linking of amino acid residues, or cyclization or cleavage of internal amino acid residues. In some cases, the post-translation modification is a self-processing event, whereas in others, another processing enzyme is required. The characterization of protein-derived cofactors and their mechanisms of biogenesis introduce a new dimension to our current views about protein evolution and protein structure-function relationships.
酶学、结构生物学和蛋白质化学领域的最新进展扩展了辅因子依赖性酶催化领域的范围。据记载，催化和具有氧化还原活性的辅基可能源自蛋白质氨基酸残基的翻译后修饰。这些蛋白质衍生的辅因子通常来自芳香族残基的氧化、氨基酸残基的共价交联，或内部氨基酸残基的环化或裂解。在某些情况下，翻译后修饰是一个自我加工事件，而在其他情况下，则需要另一种加工酶。蛋白质衍生辅因子的表征及其生物合成机制为我们目前关于蛋白质进化和蛋白质结构-功能关系的观点引入了一个新的维度。
