Shakir Yasameen A, Samsioe Göran, Khatibi E Ali, Nyberg Per, Lidfeldt Jonas, Agardh Carl-David, Nerbrand Christina
Department of Clinical Sciences in Lund, Lund University, Lund, Sweden.
J Womens Health (Larchmt). 2007 Apr;16(3):406-14. doi: 10.1089/jwh.2006.0056.
To delineate the health profile in middle-aged women with cardiovascular disease (CVD).
The Women's Health in the Lund Area (WHILA) project covered all women born 1935-1945 (n = 10,766) living in the Lund area; 6917 (64.2%) women completed a generic questionnaire and underwent physical and laboratory assessments. Of the 6917 women, 6416 were postmenopausal women, of whom 104 had CVD. For each woman with CVD, two controls were selected and matched for age, smoking habits, body mass index (BMI), waist/hip ratio (WHR), low-density lipoprotein cholesterol (LDL-C), high-density liproprotein cholesterol (HDL-C), diastolic blood pressure and hormonal status.
One hundred four women (1.6%) reported CVD. Forty-nine had a myocardial infarction (MI), 49 had a stroke, and 6 women had both events; 71.4% were postmenopausal, with never use of hormone therapy (HT) (PM0), and 28.6% were postmenopausal with ever use of HT (PMT). Compared with the control group, serum androstendione was lower (p = 0.004) in the case group, and menopausal estradiol (E(2)) values were less frequent (p = 0.037) in cases from the PM0 group. Among psychological and somatic symptoms, nervousness (p < 0.05), difficulty relaxing, crying easily, visual disturbance (p </= 0.01 for all), dizziness, difficulties in voiding urine, shortness of breath, breast tenderness, and constipation (p </= 0.001 for all) were more common among women with CVD. Women with CVD expressed less satisfaction with feeling healthy, body image, memory loss, irritability, and sexuality (p </= 0.05 for all). The case group had more problems with daily activities, more days spent in hospital during the previous 5 years, and more regular medical appointments with healthcare centers, more often had diabetes mellitus (DM) (p < 0.001 for all), and had experienced more falls in the previous year (p < 0.05). Urinary incontinence and decreased body weight were more common among cases (p </= 0.01 for both).
Several health hazards as well as somatic and psychological symptoms were more common in subjects with CVD, rendering them more susceptible to future disease.
描绘患有心血管疾病（CVD）的中年女性的健康状况。
隆德地区女性健康（WHILA）项目涵盖了所有1935年至1945年出生（n = 10766）居住在隆德地区的女性；6917名（64.2%）女性完成了一份通用问卷并接受了体格和实验室评估。在这6917名女性中，6416名是绝经后女性，其中104名患有CVD。对于每名患有CVD的女性，选择两名对照并在年龄、吸烟习惯、体重指数（BMI）、腰臀比（WHR）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、舒张压和激素状态方面进行匹配。
104名女性（1.6%）报告患有CVD。49名有心肌梗死（MI），49名有中风，6名女性两种情况都有；71.4%是绝经后女性，从未使用过激素治疗（HT）（PM0），28.6%是绝经后且曾使用过HT（PMT）。与对照组相比，病例组血清雄烯二酮较低（p = 0.004），PM0组病例中的绝经后雌二醇（E₂）值出现频率较低（p = 0.037）。在心理和躯体症状方面，紧张（p < 0.05）、难以放松、容易哭泣、视觉障碍（所有p≤0.01）、头晕、排尿困难、呼吸急促、乳房压痛和便秘（所有p≤0.001）在患有CVD的女性中更常见。患有CVD的女性在对健康感觉、身体形象、记忆力减退、易怒和性功能方面的满意度较低（所有p≤0.05）。病例组在日常活动方面有更多问题，在前一年住院天数更多，更频繁地到医疗中心定期就诊，更常患有糖尿病（DM）（所有p < 0.001），并且在前一年跌倒次数更多（p < 0.05）。尿失禁和体重减轻在病例中更常见（两者p≤0.01）。
在患有CVD的受试者中，几种健康危害以及躯体和心理症状更常见，使她们更容易患未来疾病。
