Department of Obstetrics & Gynecology, Lund University Hospital, 221 85 Lund, Sweden.
Maturitas. 2010 Jan;65(1):37-45. doi: 10.1016/j.maturitas.2009.11.009. Epub 2009 Dec 3.
The Women's Health in the Lund Area (WHILA) study invited all women (n=10,766) living in the Lund area of Southern Sweden by 1995, who were born between 1935 and 1945. The health screening program included a postal validated questionnaire concerning medical history, drug treatment, family history of diabetes and hypertension, menopausal status, smoking and alcohol habits, education, household, and working status, physical activity, quality of life as well as subjective physical and mental symptoms. The screening consisted of a routine physical examination with standardized blood pressure measurements, bone densitometry and an extended laboratory examination. A link with the mammography registry was established. Based on menopausal status, the population was divided in three subgroups; premenopausal (PM), postmenopausal with hormone replacement therapy (PMT), and postmenopausal without hormone replacement therapy (PM0). Menopause was defined as a bleed-free interval of at least 12 months. Of 10,766 women, 6917 (64.2%) had complete data sets. A number of observational analyses were carried out based on the screening data at baseline, to be followed by long-term follow-up analyses based on national register linkages that are currently being started.
隆德地区女性健康研究（WHILA）于 1995 年邀请了所有居住在瑞典南部隆德地区的女性（n=10766）参加，这些女性的出生年份在 1935 年至 1945 年之间。健康筛查计划包括邮寄的调查问卷，内容涉及个人病史、药物治疗、糖尿病和高血压家族史、绝经状态、吸烟和饮酒习惯、教育、家庭和工作状况、身体活动、生活质量以及主观的身心症状。筛查包括常规体格检查、标准化血压测量、骨密度测定和扩展实验室检查。还建立了与乳腺 X 光摄影登记处的联系。根据绝经状态，将人群分为三个亚组：绝经前（PM）、绝经后激素替代治疗（PMT）和绝经后无激素替代治疗（PM0）。绝经定义为无出血间隔至少 12 个月。在 10766 名女性中，有 6917 名（64.2%）有完整的数据集。根据基线筛查数据进行了一些观察性分析，随后将根据当前正在开始的国家登记处链接进行长期随访分析。
