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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Grote Helen E, Hannan Anthony J

University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom.

Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):533-45. doi: 10.1111/j.1440-1681.2007.04610.x.

In recent decades evidence has accumulated demonstrating the birth and functional integration of new neurons in specific regions of the adult mammalian brain, including the dentate gyrus of the hippocampus and the subventricular zone. 2. Studies in a variety of models have revealed genetic, environmental and pharmacological factors that regulate adult neurogenesis. The present review examines some of the molecular and cellular mechanisms that could be mediating these regulatory effects in both the normal and dysfunctional brain. 3. The dysregulation of adult neurogenesis may contribute to the pathogenesis of neurodegenerative disorders, such as Huntington's, Alzheimer's and Parkinson's disease, as well as psychiatric disorders such as depression. Recent evidence supports this idea and, furthermore, also indicates that factors promoting neurogenesis can modify the onset and progression of specific brain disorders, including Huntington's disease and depression.

近几十年来，越来越多的证据表明，成年哺乳动物大脑的特定区域，包括海马体的齿状回和脑室下区，会产生新的神经元并实现功能整合。2. 对多种模型的研究揭示了调节成年神经发生的遗传、环境和药理学因素。本综述探讨了一些可能在正常和功能失调的大脑中介导这些调节作用的分子和细胞机制。3. 成年神经发生的失调可能导致神经退行性疾病（如亨廷顿舞蹈症、阿尔茨海默病和帕金森病）以及精神疾病（如抑郁症）的发病机制。最近的证据支持了这一观点，此外，还表明促进神经发生的因素可以改变特定脑部疾病（包括亨廷顿舞蹈症和抑郁症）的发病和进展。

Grote Helen E, Hannan Anthony J

University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom.

Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):533-45. doi: 10.1111/j.1440-1681.2007.04610.x.

In recent decades evidence has accumulated demonstrating the birth and functional integration of new neurons in specific regions of the adult mammalian brain, including the dentate gyrus of the hippocampus and the subventricular zone. 2. Studies in a variety of models have revealed genetic, environmental and pharmacological factors that regulate adult neurogenesis. The present review examines some of the molecular and cellular mechanisms that could be mediating these regulatory effects in both the normal and dysfunctional brain. 3. The dysregulation of adult neurogenesis may contribute to the pathogenesis of neurodegenerative disorders, such as Huntington's, Alzheimer's and Parkinson's disease, as well as psychiatric disorders such as depression. Recent evidence supports this idea and, furthermore, also indicates that factors promoting neurogenesis can modify the onset and progression of specific brain disorders, including Huntington's disease and depression.

近几十年来，越来越多的证据表明，成年哺乳动物大脑的特定区域，包括海马体的齿状回和脑室下区，会产生新的神经元并实现功能整合。2. 对多种模型的研究揭示了调节成年神经发生的遗传、环境和药理学因素。本综述探讨了一些可能在正常和功能失调的大脑中介导这些调节作用的分子和细胞机制。3. 成年神经发生的失调可能导致神经退行性疾病（如亨廷顿舞蹈症、阿尔茨海默病和帕金森病）以及精神疾病（如抑郁症）的发病机制。最近的证据支持了这一观点，此外，还表明促进神经发生的因素可以改变特定脑部疾病（包括亨廷顿舞蹈症和抑郁症）的发病和进展。