Fujimura M, Ozawa S, Matsuda T
Third Department of Internal Medicine, Kanazawa University, School of Medicine, Japan.
J Asthma. 1991;28(6):419-24. doi: 10.3109/02770909109110624.
To examine whether prostacyclin has an attenuating effect on nonspecific bronchial responsiveness in asthma, we measured provocative concentration of methacholine producing a 20% fall in forced expiratory volume in 1 second (PC20-FEV1) before and after oral administration of a chemically stable prostacyclin analog (OP-41483) (200 micrograms 4 times a day for 4 days) in 8 patients with stable asthma. Neither baseline pulmonary function nor PC20-FEV1 significantly improved after the treatment. These results suggest that prostacyclin may have no direct effect on bronchial responsiveness in asthmatics. Further studies using more potent and long-lasting prostacyclin mimetic will be needed to confirm the conclusion.
为研究前列环素对哮喘患者非特异性支气管反应性是否具有减弱作用，我们对8例稳定期哮喘患者口服一种化学性质稳定的前列环素类似物（OP-41483）（每日4次，每次200微克，共4天）前后，测量了使第一秒用力呼气量（FEV1）下降20%时的乙酰甲胆碱激发浓度（PC20-FEV1）。治疗后，基线肺功能和PC20-FEV1均未显著改善。这些结果表明，前列环素可能对哮喘患者的支气管反应性无直接作用。需要进一步开展使用更有效且持久的前列环素模拟物的研究来证实这一结论。
