哮喘和鼻支气管综合征患者非特异性支气管反应性与基线肺功能的相关性

Correlation of nonspecific bronchial responsiveness to baseline pulmonary function in patients with asthma and sinobronchial syndrome.

作者信息

Fujimura M, Kamio Y, Hashimoto T, Matsuda T

机构信息

Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.

出版信息

Intern Med. 1993 Jan;32(1):1-5. doi: 10.2169/internalmedicine.32.1.

DOI:10.2169/internalmedicine.32.1

PMID:8495036

Abstract

To examine the relationship of nonspecific bronchial responsiveness to baseline pulmonary function, and to compare the reactivity in asthma and sinobronchitis, we measured the provocative concentration of methacholine, causing a 20% fall in forced expiratory volume in one second (PC20-FEV1) in 82 asthmatic patients, 54 patients with sinobronchial syndrome and 57 normal subjects. Log PC20-FEV1 was directly correlated to baseline pulmonary function. The strongest correlation was seen between log PC20-FEV1 and baseline FEV1 as a % of the predicted FEV1 (%FEV1), both in asthma (log PC20-FEV1 = 0.020 x %FEV1-1.988, r = 0.54, p < 0.01) and in sinobronchial syndrome (log PC20-FEV1 = 0.025 x %FEV1-1.233, r = 0.64, p < 0.01). From the regression equations, the mean value of PC20-FEV1 at 100% FEV1 was calculated as 1.02 and 18.5 mg/ml in asthmatic and sinobronchitic patients, respectively, and the value was 35.5 mg/ml in normal subjects. The PC20-FEV1 to %FEV1 relationship may be helpful to assess individually measured PC20-FEV1 values in patients with airway obstruction.

摘要

为研究非特异性支气管反应性与基线肺功能的关系，并比较哮喘和鼻支气管炎患者的反应性，我们测定了82例哮喘患者、54例鼻支气管综合征患者和57例正常受试者的乙酰甲胆碱激发浓度，即引起一秒用力呼气容积（FEV1）下降20%时的浓度（PC20-FEV1）。对数PC20-FEV1与基线肺功能直接相关。在哮喘患者（对数PC20-FEV1 = 0.020×%FEV1 - 1.988，r = 0.54，p < 0.01）和鼻支气管综合征患者（对数PC20-FEV1 = 0.025×%FEV1 - 1.233，r = 0.64，p < 0.01）中，对数PC20-FEV1与作为预计FEV1百分比的基线FEV1（%FEV1）之间的相关性最强。根据回归方程，计算出哮喘患者和鼻支气管炎患者在FEV1为100%时PC20-FEV1的平均值分别为1.02和18.5 mg/ml，正常受试者的值为35.5 mg/ml。PC20-FEV1与%FEV1的关系可能有助于评估气道阻塞患者个体测量的PC20-FEV1值。