Rothenberg Ellen V
Division of Biology, 156-29, California Institute of Technology, Pasadena, California 91125, USA.
Nat Immunol. 2007 May;8(5):441-4. doi: 10.1038/ni1461.
This special issue highlights a pivotal set of regulatory molecules that have emerged as central controllers of cell-type identity in the immune system. Each in its own way has been considered as a kind of 'master' regulator of a particular cell fate choice, but the actual modes of action of these factors vary widely. The comparison among them sheds light on the different ways that an essential regulatory input can affect cellular identity.
本期特刊重点介绍了一组关键的调控分子，它们已成为免疫系统中细胞类型身份的核心控制因子。每一种调控分子都以其独特的方式被视为特定细胞命运选择的某种“主”调节因子，但这些因子的实际作用模式差异很大。对它们进行比较有助于揭示一种重要的调控输入影响细胞身份的不同方式。
