Davis Mark M
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
Nat Immunol. 2007 May;8(5):445-7. doi: 10.1038/ni0507-445.
Blimp-1 is a transcription factor that affects the expression of hundreds of genes in lymphocytes. Recent work confirmed its role in the maturation of B cells into immunoglobulin-secreting plasmablasts, as well as in the control of T cell homeostasis and tolerance. What follows is a short history of how Blimp-1 was discovered.
Blimp-1是一种转录因子，可影响淋巴细胞中数百种基因的表达。最近的研究证实了它在B细胞成熟为分泌免疫球蛋白的浆母细胞过程中的作用，以及在T细胞稳态和耐受性控制中的作用。以下是Blimp-1被发现的简短历程。
