T细胞依附于Blimp-1。

T cells climb on board Blimp-1.

作者信息

Jameson Stephen C

机构信息

Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Trends Immunol. 2006 Aug;27(8):349-51. doi: 10.1016/j.it.2006.06.002. Epub 2006 Jun 27.

DOI:10.1016/j.it.2006.06.002

PMID:16807109

Abstract

B lymphocyte-induced maturation protein (Blimp)-1, a transcriptional repressor, has long been known to drive the terminal maturation of B cells into plasma cells. However, two recent studies reveal an unanticipated role for Blimp-1 in T-cell homeostasis. Blimp-1-deficient T cells exhibit enhanced proliferative and functional responses following activation, and induce spontaneous colitis. Hence, aside from its role in B-cell differentiation, Blimp-1 directs restraint among T cells.

摘要

B淋巴细胞诱导成熟蛋白（Blimp）-1是一种转录抑制因子，长期以来一直被认为可驱动B细胞终末分化为浆细胞。然而，最近的两项研究揭示了Blimp-1在T细胞稳态中出人意料的作用。缺乏Blimp-1的T细胞在激活后表现出增强的增殖和功能反应，并诱发自发性结肠炎。因此，除了在B细胞分化中的作用外，Blimp-1还可调控T细胞。