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治疗结果促使针对贲门失弛缓症症状进行再次手术的海勒肌切开术。

Outcomes promote reoperative Heller myotomy for symptoms of achalasia.

作者信息

Rakita S, Villadolid D, Kalipersad C, Thometz D, Rosemurgy A

机构信息

Department of Surgery, University of South 12901 Florida, Bruce B. Downs Blvd., Tampa, Florida 33612, USA.

出版信息

Surg Endosc. 2007 Oct;21(10):1709-14. doi: 10.1007/s00464-007-9226-8. Epub 2007 Apr 14.

Abstract

BACKGROUND

Heller myotomy is accepted as first-line therapy for achalasia, yet for a small number of patients, symptoms persist or recur after myotomy. This study was undertaken to report our results with reoperative laparoscopic Heller myotomy for recurrent symptoms of achalasia.

METHODS

We have undertaken laparoscopic Heller myotomy in 275 patients and reoperative myotomy in 12 patients for recurrent dysphagia, of which three had their initial myotomy undertaken by us. For each, studies prior to reoperative Heller myotomy documented a nonrelaxing lower esophageal sphincter without stricture. Patients scored symptoms before and after reoperative myotomy.

RESULTS

Before reoperative myotomy, 75% underwent dilation and 42% underwent Botox injection. Ten of twelve reoperative myotomies were undertaken and completed laparoscopically. Median follow-up is 24.1 months (29.0 months + 25.89). Symptom frequency and severity scores improved significantly after reoperative myotomy. Frequency of vomiting and frequency and severity of heartburn were improved after reoperative myotomy, but not to a significant extent. However, they were not particularly notable prior to surgery, compared to obstructive symptoms, such as dysphagia. Excellent or good outcomes were reported in 73%, and notably, 91% stated that they would have the operation again after having been through the process firsthand and knowing their outcomes.

CONCLUSION

Patient outcomes promote the application of reoperative Heller myotomy for recurrent or persistent symptoms of achalasia following Heller myotomy.

摘要

背景

贲门失弛缓症的一线治疗方法是赫勒肌切开术,但仍有少数患者在肌切开术后症状持续或复发。本研究旨在报告我们对贲门失弛缓症复发症状行再次手术腹腔镜赫勒肌切开术的结果。

方法

我们对275例患者进行了腹腔镜赫勒肌切开术,对12例复发性吞咽困难患者进行了再次手术肌切开术,其中3例患者的初次肌切开术由我们实施。对于每例患者,再次手术赫勒肌切开术前的检查记录显示食管下括约肌不松弛且无狭窄。患者在再次手术肌切开术前和术后对症状进行评分。

结果

再次手术肌切开术前,75%的患者接受了扩张治疗,42%的患者接受了肉毒杆菌毒素注射。12例再次手术肌切开术中,有10例通过腹腔镜完成。中位随访时间为24.1个月(29.0个月±25.89)。再次手术肌切开术后,症状频率和严重程度评分显著改善。再次手术肌切开术后,呕吐频率以及烧心的频率和严重程度有所改善,但改善程度不显著。然而,与吞咽困难等梗阻性症状相比,这些症状在手术前并不特别明显。73%的患者报告结果为优或良,值得注意的是,91%的患者表示在亲身经历并了解结果后愿意再次接受手术。

结论

患者的治疗结果支持对赫勒肌切开术后贲门失弛缓症复发或持续症状应用再次手术赫勒肌切开术。

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