Zhao Qiang, Wu Tong-Guo, Jiang Zuo-Fen, Chen Guo-Wei, Lin Yi, Wang Le-Xin
Department of Cardiology, The Red Cross Hospital of Guangzhou City, the Fourth Affiliated Hospital of Jinan University, Guangzhou 510220, People's Republic of China.
Cardiovasc Drugs Ther. 2007 Apr;21(2):85-90. doi: 10.1007/s10557-007-6016-4.
To investigate the expression of beta(3)-adrenoceptors in rats with chronic heart failure, and to explore the effect of beta-blockers on beta(3)-adrenoceptor expression.
Thirty-two male Wistar rats were divided into Sham (n = 10) and heart failure (n = 22) groups. The heart failure group was treated with normal saline (Heart Failure Control, n = 6), Metoprolol (n = 8) or Carvedilol (n = 8) for 3 months.
The left ventricular end systolic pressure (LVESP) and the absolute values of maximal rate of rise and fall of left ventricular pressure (+/-dP/dt max) in the heart failure group were lower than in the Sham group (P < 0.01), whereas the left ventricular end diastolic pressure (LVEDP) was higher (P < 0.01). The LVESP and dP/dtmax in the Carvedilol group were higher than the Metoprolol group whereas LVEDP was lower (P < 0.01). The left ventricular mass index (LVMI) in the Carvedilol group was less than the Metoprolol and Heart Failure Control groups (P < 0.01). The level of beta(3)-adrenoceptor expression in the study groups was significantly higher than the Sham group (P < 0.01). beta(3)-adrenoceptor expression in the Carvedilol group was lower than the Heart Failure Control and Metoprolol groups (P < 0.01).
beta(3)-adrenoceptor expression is increased in the failing ventricles in rats. Carvedilol is more effective than Metoprolol for improving the hemodynamics and in attenuating ventricular remodeling after heart failure. Carvedilol, rather than Metoprolol, diminishes beta(3)-adrenoceptor expression in the failing ventricles.
研究慢性心力衰竭大鼠β3 - 肾上腺素能受体的表达，并探讨β受体阻滞剂对β3 - 肾上腺素能受体表达的影响。
32只雄性Wistar大鼠分为假手术组（n = 10）和心力衰竭组（n = 22）。心力衰竭组分别用生理盐水（心力衰竭对照组，n = 6）、美托洛尔（n = 8）或卡维地洛（n = 8）治疗3个月。
心力衰竭组左心室收缩末期压力（LVESP）、左心室压力最大上升和下降速率的绝对值（±dP/dt max）低于假手术组（P < 0.01），而左心室舒张末期压力（LVEDP）高于假手术组（P < 0.01）。卡维地洛组的LVESP和dP/dt max高于美托洛尔组，而LVEDP低于美托洛尔组（P < 0.01）。卡维地洛组左心室质量指数（LVMI）小于美托洛尔组和心力衰竭对照组（P < 0.01）。研究组β3 - 肾上腺素能受体表达水平显著高于假手术组（P < 0.01）。卡维地洛组β3 - 肾上腺素能受体表达低于心力衰竭对照组和美托洛尔组（P < 0.01）。
大鼠衰竭心室中β3 - 肾上腺素能受体表达增加。卡维地洛在改善心力衰竭后血流动力学和减轻心室重构方面比美托洛尔更有效。卡维地洛而非美托洛尔可降低衰竭心室中β3 - 肾上腺素能受体的表达。
