Lu Yiye, Liu Li, Guo Shengrong
School of Pharmacy, Shanghai Jiaotong University, Shanghai, PR China.
Biopolymers. 2007;86(5-6):403-8. doi: 10.1002/bip.20743.
Chitosan-g-PCL-b-MPEG copolymers of various compositions were successful synthesized via a protection-graft-deprotection procedure, by the esterification of phthaloyl-protected chitosan (PHCS) with MPEG-b-PCL-COOH, which was synthesized from MPEG and epsilon-caprolactone and carboxylated by maleic anhydride. The chemical structure of the chitosan-g-PCL-b-MPEG was characterized by Fourier transform infrared and NMR spectroscopy. The chitosan-g-PCL-b-MPEG was obtained as amphoteric hybrid with amino polysaccharide backbone and amphiphilic MPEG-b-PCL side chain. Their crystallinity and aggregation behavior in aqueous solution were also investigated.
通过保护-接枝-脱保护过程，成功合成了各种组成的壳聚糖-g-聚己内酯-b-甲氧基聚乙二醇（MPEG）共聚物，该过程是通过邻苯二甲酰保护的壳聚糖（PHCS）与MPEG-b-聚己内酯-COOH进行酯化反应实现的，MPEG-b-聚己内酯-COOH由MPEG和ε-己内酯合成，并通过马来酸酐进行羧化。通过傅里叶变换红外光谱和核磁共振光谱对壳聚糖-g-聚己内酯-b-MPEG的化学结构进行了表征。壳聚糖-g-聚己内酯-b-MPEG是以具有氨基多糖主链和两亲性MPEG-b-聚己内酯侧链的两性杂化物形式获得的。还研究了它们在水溶液中的结晶度和聚集行为。
