Institute of Polymers Chemistry and Technology, C.N.R.-Via Campi Flegrei, 34-80078 Pozzuoli, Naples, Italy.
Mar Drugs. 2010 Sep 2;8(9):2435-65. doi: 10.3390/md8092435.
The enormous variety of polysaccharides that can be extracted from marine plants and animal organisms or produced by marine bacteria means that the field of marine polysaccharides is constantly evolving. Recent advances in biological techniques allow high levels of polysaccharides of interest to be produced in vitro. Biotechnology is a powerful tool to obtain polysaccharides from a variety of micro-organisms, by controlling the growth conditions in a bioreactor while tailoring the production of biologically active compounds. Following an overview of the current knowledge on marine polysaccharides, with special attention to potential pharmaceutical applications and to more recent progress on the discovering of new polysaccharides with biological appealing characteristics, this review will focus on possible strategies for chemical or physical modification aimed to tailor the final properties of interest.
从海洋植物和动物生物中提取或由海洋细菌产生的多糖种类繁多，这意味着海洋多糖领域在不断发展。生物技术的最新进展使得可以在体外大量生产感兴趣的多糖。生物技术是一种从各种微生物中获得多糖的有力工具，通过在生物反应器中控制生长条件，同时定制具有生物活性化合物的生产。在概述了当前关于海洋多糖的知识之后，特别关注其潜在的药物应用，以及在发现具有生物吸引力特征的新型多糖方面的最新进展，本综述将重点介绍旨在调整最终感兴趣特性的化学或物理修饰的可能策略。
