前列腺液的分子PCA3诊断
Molecular PCA3 diagnostics on prostatic fluid.
作者信息
van Gils Martijn P M Q, Cornel Erik B, Hessels Daphne, Peelen W Pim, Witjes J Alfred, Mulders Peter F A, Rittenhouse Harry G, Schalken Jack A
机构信息
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
出版信息
Prostate. 2007 Jun 1;67(8):881-7. doi: 10.1002/pros.20564.
BACKGROUND
The PCA3 test on urine can improve specificity in prostate cancer (PCa) diagnosis and could prevent unnecessary prostate biopsies. In this study, we evaluated the PCA3 test on prostatic fluid and compared this with the PCA3 test on urine in a clinical research setting.
METHODS
Prostatic fluid and urine samples from 67 men were collected following digital rectal examination (DRE). The sediments were analyzed using the quantitative APTIMA PCA3 test. The results were compared with prostate biopsy results.
RESULTS
Using a PCA3 score of 66 as a cut-off value, the test on prostatic fluid had 65% sensitivity for the detection of PCa, 82% specificity and a negative predictive value of 82%. At a cut-off value of 43, the test on urine had 61% sensitivity, 80% specificity and a negative predictive value of 80%.
CONCLUSIONS
The PCA3 test can be performed on both urine and prostatic fluid in the diagnosis of PCa with comparable results.
背景
尿液PCA3检测可提高前列腺癌（PCa）诊断的特异性，并可避免不必要的前列腺活检。在本研究中，我们在临床研究环境中评估了前列腺液的PCA3检测，并将其与尿液的PCA3检测进行了比较。
方法
在直肠指检（DRE）后收集67名男性的前列腺液和尿液样本。使用定量APTIMA PCA3检测分析沉淀物。将结果与前列腺活检结果进行比较。
结果
以PCA3评分66作为临界值，前列腺液检测对PCa检测的灵敏度为65%，特异性为82%，阴性预测值为82%。以临界值43时，尿液检测的灵敏度为61%，特异性为80%，阴性预测值为80%。
结论
PCA3检测可用于尿液和前列腺液的PCa诊断，结果相当。
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