Bernoulli Jenni, Yatkin Emrah, Talvitie Eva-Maria, Santti Risto, Streng Tomi
Institute of Biomedicine, Department of Anatomy, University of Turku, Turku, Finland.
Prostate. 2007 Jun 1;67(8):888-99. doi: 10.1002/pros.20567.
Chronic nonbacterial prostatitis (CP) associated with voiding dysfunction is a poorly understood clinical phenomenon. The goal of the present study was to induce prostatic inflammation with estrogen and androgen treatment and to record associated urodynamic changes in Noble rats.
Rats were treated with estradiol and testosterone implants to increase estradiol concentration in serum while testosterone concentration was maintained at or slightly above the control level. The urodynamical recordings were performed under anesthesia after the hormone treatments for 3 and 6 weeks. The dorsolateral lobes of the prostates were removed for histopathological analysis after recordings.
After the 3-week treatment, lymphocytes, mainly T-cells, were located around the capillaries. During the following 3 weeks lymphocytes migrated into stroma and acini. Cytotoxic T-cells were seen intraepithelially, and neutrophiles inside the acini. Removal of estrogen implant or treatment with anti-estrogen diminished inflammation. No changes in voiding pattern were seen after the 3-week treatment. Three weeks later, bladder weight and capacity were increased, and the micturition time was prolonged.
Elevated estrogen concentration was essential for the gradual development of prostatic inflammation. The profile and location of inflammatory cells suggest that prostatic vasculature is one of the sites of estrogen action. Urodynamic changes which developed in association with glandular inflammation indicated abnormal bladder function, reflecting an incipient obstruction.
与排尿功能障碍相关的慢性非细菌性前列腺炎（CP）是一种了解甚少的临床现象。本研究的目的是通过雌激素和雄激素治疗诱导前列腺炎症，并记录诺布尔大鼠相关的尿动力学变化。
给大鼠植入雌二醇和睾酮，以提高血清雌二醇浓度，同时将睾酮浓度维持在对照水平或略高于对照水平。在激素治疗3周和6周后，于麻醉状态下进行尿动力学记录。记录后，切除前列腺的背外侧叶进行组织病理学分析。
3周治疗后，淋巴细胞（主要是T细胞）位于毛细血管周围。在接下来的3周内，淋巴细胞迁移到基质和腺泡中。上皮内可见细胞毒性T细胞，腺泡内可见中性粒细胞。去除雌激素植入物或用抗雌激素治疗可减轻炎症。3周治疗后排尿模式未见变化。3周后，膀胱重量和容量增加，排尿时间延长。
雌激素浓度升高对前列腺炎症的逐渐发展至关重要。炎症细胞的分布和位置表明前列腺血管系统是雌激素作用的部位之一。与腺体炎症相关的尿动力学变化表明膀胱功能异常，反映了早期梗阻。
