Saria Marlon G, Gosselin-Acomb Tracy K
University of California, San Diego Medical Center, USA.
Clin J Oncol Nurs. 2007 Feb;11(1):53-63. doi: 10.1188/07.CJON.53-63.
Hematopoietic stem cell transplantation (HSCT) is being used increasingly in the treatment of malignant and nonmalignant diseases. The treatment modality has been proven effective but is not without risks. Studies consistently have identified the need for advanced supportive care (e.g., multiple organ dysfunction, vasopressor use, mechanical ventilation) as a negative prognostic indicator in patients who have received HSCT. Among patients who have received HSCT, 15%-40% require critical care monitoring or advanced support. Nurses on intensive care units can positively impact outcomes for transplant recipients when they possess the specialized skills to recognize and promptly intervene when transplant-related complications arise. This article will provide a basic overview of the HSCT process and outline the complications that may necessitate transfer to a higher level of care for specialized skills and equipment in the intensive care setting.
造血干细胞移植（HSCT）越来越多地用于治疗恶性和非恶性疾病。这种治疗方式已被证明是有效的，但并非没有风险。研究一致认为，对于接受HSCT的患者，需要高级支持治疗（如多器官功能障碍、使用血管加压药、机械通气）是一个不良预后指标。在接受HSCT的患者中，15%-40%需要重症监护监测或高级支持。当重症监护病房的护士具备识别移植相关并发症并在其出现时及时干预的专业技能时，他们可以对移植受者的治疗结果产生积极影响。本文将提供HSCT过程的基本概述，并概述可能需要转至更高护理级别以获得重症监护环境中的专业技能和设备的并发症。
