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护理在肝窦阻塞综合征患者评估和护理中的作用:“意大利骨髓移植组”的共识文件。

Nursing role in the assessment and care of hepatic sinusoidal obstruction syndrome patients: a consensus paper by the "Gruppo Italiano Trapianto di Midollo Osseo".

机构信息

Haematology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Bone Marrow Transplant Unit Denis Burkitt, St. James's Hospital, Dublin, Ireland.

出版信息

Support Care Cancer. 2020 Nov;28(11):5125-5137. doi: 10.1007/s00520-020-05353-9. Epub 2020 Feb 13.

DOI:10.1007/s00520-020-05353-9
PMID:32056012
Abstract

PURPOSE

Sinusoidal obstruction syndrome (SOS) is one of the most serious complications post haematopoietic stem cell transplantation (HSCT). The diagnosis of SOS is clinical, but nurses should be involved in the pre-transplant risk assessment period and play a crucial role in the early detection of signs and symptoms during and after hospitalization. The aim of this work is to achieve a consensus on nurses' behaviour in caring for SOS.

METHODS

On behalf of the Italian Group for Bone and Marrow Transplantation (GITMO), a promoter committee was established to put in place a consensus conference approach. A multidisciplinary group of GITMO together with four nurses, three haematology physicians and one patient representative acted as jury, who reviewed the reports and wrote recommendations and suggestions. Recommendations gaining 100% of consensus were considered 'Golden Points of Care'; if a consensus was achieved by ≥ 75% of the jury's members, those recommendations were defined as 'Good Practices'.

RESULTS

Eighteen papers written by nurses as first authors have been identified. Golden Points of Care and Good Practices were worked out for the following topics: nurses' role in general, nurses' role in pre-transplant assessment, pre-transplant risk assessment and risk stratification, baseline monitoring, suspected mild or moderate SOS, suspected severe or very severe SOS and late-onset cases.

CONCLUSION

SOS is relatively rare; therefore, a holistic approach to the patients' needs considering nursing role as essential may result in better care outcomes.

摘要

目的

正弦阻塞综合征(SOS)是造血干细胞移植(HSCT)后最严重的并发症之一。SOS 的诊断是临床诊断,但护士应参与移植前风险评估期,并在住院期间和住院后早期检测体征和症状方面发挥关键作用。这项工作的目的是就护士在护理 SOS 方面的行为达成共识。

方法

代表意大利骨髓移植组(GITMO),成立了一个发起人委员会,以实施共识会议方法。GITMO 的一个多学科小组与四名护士、三名血液科医生和一名患者代表一起担任陪审团,他们审查了报告并撰写了建议和意见。获得 100%共识的建议被视为“护理黄金要点”;如果陪审团成员≥75%达成共识,则这些建议被定义为“良好实践”。

结果

确定了由护士作为第一作者撰写的 18 篇论文。针对以下主题制定了护理黄金要点和良好实践:护士的一般角色、护士在移植前评估中的角色、移植前风险评估和风险分层、基线监测、疑似轻度或中度 SOS、疑似严重或非常严重 SOS 和迟发性病例。

结论

SOS 相对较少见;因此,考虑到护理角色至关重要的患者需求的整体方法可能会带来更好的护理结果。

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本文引用的文献

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Ultrasound elastography techniques for diagnosis and follow-up of hepatic veno-occlusive disease.用于肝静脉闭塞病诊断及随访的超声弹性成像技术
Bone Marrow Transplant. 2019 Jul;54(7):1145-1147. doi: 10.1038/s41409-019-0432-5. Epub 2019 Jan 24.
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Identification and Management: Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease Eelated to Hematopoietic Stem Cell Transplantation
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Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.
儿童患者窦状隙阻塞综合征/静脉阻塞性疾病的诊断和严重程度标准:来自欧洲血液和骨髓移植学会的新分类。
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Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment.儿科急性肺损伤和脓毒症研究人员与儿科血液和骨髓移植联盟联合工作组共识报告:静脉阻塞性疾病患儿和青少年管理的支持性治疗指南,第 1 部分:重点关注检查、预防和具体治疗。
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New insights into sinusoidal obstruction syndrome.窦性阻塞综合征的新见解。
Intern Med J. 2017 Oct;47(10):1173-1183. doi: 10.1111/imj.13550.
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Burden of illness associated with sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation.造血干细胞移植患者中与窦性阻塞综合征/静脉闭塞性疾病相关的疾病负担
J Med Econ. 2017 Aug;20(8):871-883. doi: 10.1080/13696998.2017.1336623. Epub 2017 Jun 14.
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Eur J Haematol. 2017 Apr;98(4):322-329. doi: 10.1111/ejh.12840. Epub 2017 Feb 2.
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Veno-occlusive disease nurse management: development of a dynamic monitoring tool by the GITMO nursing group.静脉闭塞性疾病的护士管理:GITMO护理小组开发动态监测工具
Ecancermedicalscience. 2016 Aug 8;10:661. doi: 10.3332/ecancer.2016.661. eCollection 2016.
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Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.成人患者窦性阻塞综合征/静脉闭塞性疾病的修订诊断和严重程度标准:欧洲血液和骨髓移植学会的新分类
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Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.去纤苷治疗严重肝静脉闭塞病和多器官功能衰竭的3期试验。
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