外用氧化锌与水杨酸 - 乳酸组合治疗疣的对比研究
Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts.
作者信息
Khattar Joe A, Musharrafieh Umayya M, Tamim Hala, Hamadeh Ghassan N
机构信息
Department of Family Medicine, Faculty of Health Sciences, American University of Beirut Medical Center, Beirut, Lebanon.
出版信息
Int J Dermatol. 2007 Apr;46(4):427-30. doi: 10.1111/j.1365-4632.2006.03138.x.
BACKGROUND
Warts are a common dermatologic problem. Treatment is painful, prolonged, and can cause scarring.
OBJECTIVE
To evaluate topical zinc oxide for the treatment of warts.
METHODS
This was a randomized, double-blind controlled trial of 44 patients. Twenty-two patients were given topical zinc oxide 20% ointment, and the other 22 received salicylic acid 15% + lactic acid 15% ointment twice daily. All patients were followed up for 3 months or until cure, whichever occurred first. All patients were observed for side-effects.
RESULTS
Sixteen patients in the zinc group and 19 in the salicylic acid-lactic acid group completed the study. In the zinc oxide-treated group, 50% of the patients showed complete cure and 18.7% failed to respond, compared with 42% and 26%, respectively, in the salicylic acid-lactic acid-treated group. No patients developed serious side-effects.
CONCLUSION
Topical zinc oxide is an efficacious, painless, and safe therapeutic option for wart treatment.
背景
疣是一种常见的皮肤问题。治疗过程痛苦、耗时，且可能导致瘢痕形成。
目的
评估外用氧化锌治疗疣的效果。
方法
这是一项针对44例患者的随机双盲对照试验。22例患者外用20%氧化锌软膏，另外22例患者外用15%水杨酸+15%乳酸软膏，每日两次。所有患者随访3个月或直至治愈，以先发生者为准。观察所有患者的副作用。
结果
氧化锌组16例患者和水杨酸-乳酸组19例患者完成了研究。在氧化锌治疗组中，50%的患者完全治愈，18.7%无反应，而在水杨酸-乳酸治疗组中分别为42%和26%。没有患者出现严重副作用。
结论
外用氧化锌是治疗疣的一种有效、无痛且安全的治疗选择。
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