Solomon Peter S, Waters Ormonde D C, Oliver Richard P
Australian Centre for Necrotrophic Fungal Pathogens, SABC, Division of Health Sciences, Murdoch University, Perth, WA 6150, Australia.
Trends Microbiol. 2007 Jun;15(6):257-62. doi: 10.1016/j.tim.2007.04.002. Epub 2007 Apr 17.
Mannitol is a 6-carbon polyol that is among the most abundant biochemical compounds in the biosphere. Mannitol has been ascribed a multitude of roles in filamentous fungi including carbohydrate storage, reservoir of reducing power, stress tolerance and spore dislodgement and/or dispersal. The advancement of genetic manipulation techniques in filamentous fungi has rapidly accelerated our understanding of the roles and metabolism of mannitol. The targeted deletion of genes encoding proteins of mannitol metabolism in several fungi, including phytopathogens, has proven that the metabolism of mannitol does not exist as a cycle and that many of the postulated roles are unsupported. These recent studies have provided a much needed focus on this mysterious metabolite and make this a fitting time to review the roles and metabolism of mannitol in filamentous fungi.
甘露醇是一种六碳多元醇，是生物圈中最丰富的生化化合物之一。甘露醇在丝状真菌中具有多种作用，包括碳水化合物储存、还原力储备、胁迫耐受性以及孢子脱落和/或传播。丝状真菌中基因操作技术的进步迅速加快了我们对甘露醇作用和代谢的理解。在包括植物病原体在内的几种真菌中，对编码甘露醇代谢蛋白的基因进行靶向缺失已证明，甘露醇的代谢并不以循环形式存在，并且许多假定的作用缺乏依据。这些最新研究为这种神秘的代谢物提供了急需的关注重点，也使得现在成为回顾甘露醇在丝状真菌中的作用和代谢的恰当时机。
