Miyashita H, Worthington H V, Qualtrough A, Plasschaert A
Cochrane Database Syst Rev. 2007 Apr 18(2):CD004484. doi: 10.1002/14651858.CD004484.pub2.
There is a range of treatment options for the management of the pulp in extensively decayed teeth. These include direct and indirect pulp capping, pulpotomy or pulpectomy. If the tooth is symptomatic or if there are periapical bone changes, then endodontic treatment is required. However, if the tooth is asymptomatic but the caries is extensive, there is no consensus as to the best method of management. In addition, there has been a recent move towards using alternative materials and methods such as the direct or indirect placement of bonding agents and mineral trioxide aggregate. Most studies have investigated the management of asymptomatic carious teeth with or without an exposed dental pulp using various capping materials (e.g. calcium hydroxide, Ledermix, Triodent, Biorex, etc.). However, there is no long term data regarding the outcome of management of asymptomatic, carious teeth according to different regimens.
This study aims to assess the effectiveness of techniques used to treat asymptomatic carious teeth and maintain pulp vitality.
Electronic searches of the following databases were undertaken: The Cochrane Oral Health Group's Trials Register (March 2006), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2006, Issue 1), MEDLINE (1966 to week 4, February 2006), EMBASE (1974 to 13 March 2006), National Research Register (March 2006), Science Citation Index - SCISEARCH (1981 to March 2006). Detailed search strategies were developed for each database. Handsearching and screening of reference lists were undertaken. There was no restriction with regard to language of publication.
Studies included were randomised controlled trials (RCTs). Asymptomatic vital permanent teeth with extensive caries were included. Studies were those which compared techniques to maintain pulp vitality. Outcome measures included clinical success and adverse events.
Data were independently extracted by three review authors. Authors were contacted for details of randomisation and withdrawals and a quality assessment was carried out. The Cochrane Oral Health Group's statistical guidelines were followed.
Only four RCTs were identified. Interventions examined included: Ledermix, glycerrhetinic acid/antibiotic mix, zinc oxide eugenol, calcium hydroxide, Cavitec, Life, Dycal, potassium nitrate, dimethyl isosorbide, and polycarboxylate cement. Only one study showed a statistically significant finding; potassium nitrate/dimethyl isosorbide/polycarboxylate cement resulted in fewer clinical symptoms than potassium nitrate/polycarboxylate cement or polycarboxylate cement alone when used as a capping material for carious pulps.
AUTHORS' CONCLUSIONS: It was disappointing that there were so few studies which could be considered as being suitable for inclusion in this review. The findings from this review do not suggest that there should be any significant change from accepted conventional practice procedures when the pulp of the carious tooth is considered. Further well designed RCTs are needed to investigate the potential of contemporary materials which may be suitable when used in the management of carious teeth. It is recognised that it is difficult to establish the 'ideal' clinical study when ethical approval for new materials must be sought and strict attention to case selection, study protocol and interpretation of data is considered. It is also not easy to recruit sufficient numbers of patients meeting the necessary criteria.
对于广泛龋坏牙齿的牙髓处理,有一系列治疗选择。这些包括直接和间接盖髓、活髓切断术或牙髓摘除术。如果牙齿有症状或存在根尖周骨质改变,那么就需要进行根管治疗。然而,如果牙齿无症状但龋坏广泛,对于最佳处理方法尚无共识。此外,最近出现了使用替代材料和方法的趋势,如直接或间接放置粘结剂和三氧化矿物凝聚体。大多数研究使用各种盖髓材料(如氢氧化钙、Ledermix、Triodent、Biorex等)研究了有无暴露牙髓的无症状龋坏牙齿的处理。然而,尚无关于根据不同治疗方案处理无症状龋坏牙齿结果的长期数据。
本研究旨在评估用于治疗无症状龋坏牙齿并维持牙髓活力的技术的有效性。
对以下数据库进行了电子检索:Cochrane口腔健康组试验注册库(2006年3月)、Cochrane对照试验中心注册库(CENTRAL)(Cochrane图书馆2006年第1期)、MEDLINE(1966年至2006年2月第4周)、EMBASE(1974年至2006年3月13日)、国家研究注册库(2006年3月)、科学引文索引 - SCISEARCH(1981年至2006年3月)。为每个数据库制定了详细的检索策略。进行了手工检索和参考文献列表筛选。对出版物语言没有限制。
纳入的研究为随机对照试验(RCT)。纳入有无症状的活髓恒牙且龋坏广泛的情况。研究为比较维持牙髓活力技术的研究。结局指标包括临床成功和不良事件。
由三位综述作者独立提取数据。就随机化和退出的细节与作者进行了联系,并进行了质量评估。遵循了Cochrane口腔健康组的统计指南。
仅识别出四项RCT。所研究的干预措施包括:Ledermix、甘草次酸/抗生素混合物、氧化锌丁香酚、氢氧化钙、Cavitec、Life、Dycal、硝酸钾、二甲基异山梨醇和聚羧酸锌水门汀。只有一项研究显示出统计学上的显著发现;当用作龋坏牙髓的盖髓材料时,硝酸钾/二甲基异山梨醇/聚羧酸锌水门汀导致的临床症状比硝酸钾/聚羧酸锌水门汀或单独的聚羧酸锌水门汀少。
令人失望的是,几乎没有可被认为适合纳入本综述的研究。本综述的结果并不表明在考虑龋坏牙齿的牙髓时,公认的传统治疗程序应有任何重大改变。需要进一步设计良好的RCT来研究当代材料在龋坏牙齿处理中使用时的潜力。认识到当必须寻求新材料的伦理批准并严格关注病例选择、研究方案和数据解释时,很难建立“理想”的临床研究。招募足够数量符合必要标准的患者也不容易。