Structural alterations of the junctional region in extraocular muscle of dystrophic mice. I. Modifications of sole-plate nuclei.

Sole-plate nuclei of the C57Bl/6Jdy2j dystrophic mouse showed apparent selective susceptibility to various forms of structural alteration. Pyknosis and chromatin fragmentation were seen in addition to vacuolar and membranous nuclear inclusions. These were often associated with neuromuscular junctions with markedly reduced or virtually absent junctional folding. Membranous proliferations also occurred nearby sole-plate nuclei of such flattened junctions.