Annanmaki Tua, Muuronen Antti, Murros Kari
Department of Neurology of Jorvi Hospital, Helsinki University Hospital, Helsinki, Finland.
Mov Disord. 2007 Jun 15;22(8):1133-7. doi: 10.1002/mds.21502.
Earlier studies suggest that low plasma uric acid level is a risk factor for Parkinson's disease (PD), and that uric acid associates with iron-binding proteins. We therefore decided to examine plasma uric acid levels and markers of peripheral iron metabolism in PD patients and healthy controls. For the study, 40 patients with PD and 29 controls underwent clinical screening, laboratory testing, and body mass index (BMI) measurement. The average consumption of different foodstuffs and dairy products was estimated. Plasma uric acid level was significantly lower in the patients than in the controls. There were no significant differences in the levels of plasma iron parameters, but plasma uric acid correlated strongly with serum ferritin both in the patient and the control group. The BMI was slightly lower in the patients compared with the controls despite equal daily calorie consumption. Plasma uric acid level is low in patients with PD, which may have implications for both the disease pathogenesis and treatment recommendations.
早期研究表明，低血浆尿酸水平是帕金森病（PD）的一个危险因素，且尿酸与铁结合蛋白相关。因此，我们决定检测PD患者和健康对照者的血浆尿酸水平及外周铁代谢标志物。在这项研究中，40例PD患者和29名对照者接受了临床筛查、实验室检测及体重指数（BMI）测量。估算了不同食品和乳制品的平均摄入量。患者的血浆尿酸水平显著低于对照者。血浆铁参数水平无显著差异，但在患者组和对照组中，血浆尿酸均与血清铁蛋白密切相关。尽管每日热量消耗相同，但患者的BMI略低于对照者。PD患者的血浆尿酸水平较低，这可能对疾病发病机制和治疗建议均有影响。
