Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
Neurodegener Dis. 2011;8(4):252-8. doi: 10.1159/000323265. Epub 2011 Feb 1.
Oxidative stress plays a role in the pathogenesis of neuronal death. Serum levels of urate or lipid were associated with the incidence of Parkinson's disease (PD).
We compared urate, paraoxonase-1 (PON1), iron, ferritin and lipid in sera of 119 PD patients and 120 healthy controls matched by age, sex and body mass index. We aimed to elucidate whether those serological data are correlated with disease progression.
Mean age (SD) of PD patients was 73.4 (8.7) years. Mean Yahr stage (SD) was 3.2 (0.9). Mean disease duration (SD) was 6.9 (5.1) years. Mean dose of L-DOPA (SD) was 355 (157) mg/day. As compared to controls, serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), urate and PON1 activity were significantly reduced, and serum ferritin levels were significantly increased in male and female PD patients. Serum urate levels and PON1 activities were inversely related, and serum ferritin levels were correlated with Yahr stage and PD duration in men and women. Serum levels of TC and LDL-C were inversely related to Yahr stage or PD duration in female patients.
Our studies indicated serological profiles of urate, PON1, ferritin, TC and LDL-C in PD patients. These serological changes were linked to PD progression. Metabolism of lipid, oxidant- and antioxidant-related substances may contribute to the pathogenesis and the progression of PD.
氧化应激在神经元死亡的发病机制中起作用。尿酸或脂质的血清水平与帕金森病（PD）的发病率有关。
我们比较了 119 例 PD 患者和 120 例年龄、性别和体重指数匹配的健康对照者的血清尿酸、对氧磷酶 1（PON1）、铁、铁蛋白和脂质。我们旨在阐明这些血清学数据是否与疾病进展相关。
PD 患者的平均年龄（标准差）为 73.4（8.7）岁。平均 Yahr 分期（标准差）为 3.2（0.9）。平均病程（标准差）为 6.9（5.1）年。平均 L-DOPA 剂量（标准差）为 355（157）mg/天。与对照组相比，男性和女性 PD 患者的血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、尿酸和 PON1 活性明显降低，血清铁蛋白水平明显升高。血清尿酸水平与 PON1 活性呈负相关，血清铁蛋白水平与男性和女性的 Yahr 分期和 PD 病程相关。女性患者血清 TC 和 LDL-C 水平与 Yahr 分期或 PD 病程呈负相关。
我们的研究表明 PD 患者的尿酸、PON1、铁蛋白、TC 和 LDL-C 血清谱。这些血清变化与 PD 进展有关。脂质、氧化剂和抗氧化剂相关物质的代谢可能导致 PD 的发病机制和进展。
