Wang Yan, He Jichang, Kanxing Zhao, Jin Ying, Zuo Tong, Wang Wei
Refractive Surgery Center, Tianjin Eye Institute and Hospital, Teaching Hospital of Tianjin Medical University, Tianjin, China.
J Refract Surg. 2006 Nov;22(9 Suppl):S1031-6. doi: 10.3928/1081-597X-20061102-05.
To investigate the relationship between mild and moderate corneal haze and the distribution of higher order wavefront aberrations after photorefractive keratectomy (PRK).
Thirty-six eyes from 18 patients who underwent PRK were divided into two groups: 10 eyes with corneal haze and 26 eyes without corneal haze (control). All eyes were evaluated up to 6 months after PRK. Wavefront aberrations were measured using a psychophysical wavefront sensor and the NIDEK OPD-Scan. Topography, point spread function, and modulation transfer function maps were obtained from the OPD-Scan.
The mean total higher order aberration was slightly higher in the corneal haze group than in the control group. This difference was not statistically significant. The mean third order coma aberrations were higher and mean fourth order spherical aberrations were lower in the haze group compared with the control group, although neither difference attained statistical significance. The t test values were 1.05, -0.38, -1.10, -0.08, and -0.23, when comparing the mean third, fourth, fifth, sixth, and seventh order aberrations, respectively. None of these differences attained statistical significance. In terms of Zernike coefficients, Z-1 and Z1 showed greater mean root-mean-square (RMS) in the haze group (0.33 and 0.35 microm, respectively) than those for the control group (0.26 and 0.23 microm, respectively) (t=0.71 and P=.49; t=0.84 and P=.43, respectively). However, ZO had lower RMS in the haze group (0.18 microm) than in the control group (0.28 microm). This difference also was not statistically significant.
In this study comparing the optical aberrations of eyes with and without corneal haze after PRK, corneal haze did not affect the magnitude and distribution of higher order aberrations in a predictable manner.
探讨准分子激光角膜切削术（PRK）后轻度和中度角膜混浊与高阶波前像差分布之间的关系。
将18例行PRK患者的36只眼分为两组：10只角膜混浊眼和26只无角膜混浊眼（对照组）。所有眼睛在PRK后随访6个月。使用心理物理波前传感器和NIDEK OPD-Scan测量波前像差。从OPD-Scan获得地形图、点扩散函数和调制传递函数图。
角膜混浊组的平均总高阶像差略高于对照组。但这种差异无统计学意义。与对照组相比，混浊组的平均三阶彗差较高，平均四阶球差较低，尽管两者差异均未达到统计学意义。比较平均三阶、四阶、五阶、六阶和七阶像差时，t检验值分别为1.05、-0.38、-1.10、-0.08和-0.23。这些差异均无统计学意义。就泽尼克系数而言，混浊组的Z-1和Z1的平均均方根（RMS）值（分别为0.33和0.35μm）高于对照组（分别为0.26和0.23μm）（t=0.71，P=0.49；t=0.84，P=0.43）。然而，混浊组的ZO的RMS值（0.18μm）低于对照组（0.28μm）。这种差异也无统计学意义。
在本研究中，比较PRK后有和无角膜混浊眼的光学像差，角膜混浊并未以可预测的方式影响高阶像差的大小和分布。
