Erdem Uzeyir, Muftuoglu Orkun
Gulhane Military Medical Faculty, Ankara, Turkey.
J Refract Surg. 2006 Nov;22(9 Suppl):S1056-68. doi: 10.3928/1081-597X-20061102-10.
To study the factors that correlate with improved best spectacle-corrected visual acuity (BSCVA) after LASIK.
This was a nonrandomized, prospective clinical trial of 850 eyes from 480 patients undergoing LASIK for myopia, hyperopia, and mixed astigmatism. The mean preoperative spherical equivalent refraction was -3.75+/-4.82 diopters (D) (range: -13.88 to 6.00 D). From this population, 72 eyes (including 22 amblyopic eyes) from 43 patients were found to have improved BSCVA 6 months after LASIK. All patients underwent LASIK with the NAVEX platform. These eyes were analyzed to evaluate factors that correlated with improved BSCVA. Pre- and postoperative BSCVA, refraction, pupil diameter, corneal topography, asphericity (Q value), total aberrations, and higher order wavefront aberrations were analyzed. All wavefront aberrations were measured using the NIDEK Optical Path Difference Scan aberrometer (OPD-Scan) preoperatively and at 6 months postoperatively.
Postoperatively, the mean sphere was -0.44 1.30 D (range: -4.50 to +2.50 D). The mean increase in BSCVA was 0.15+/-0.09 logMAR. A statistically significant negative correlation was observed between the increase in BSCVA and the preoperative BSCVA (P<.01). Mixed astigmatic and highly myopic eyes are more likely to gain BSCVA after LASIK than moderately myopic (P<.05) and hyperopic eyes (P<.001). In patients with myopia, the amount of BSCVA improvement correlated with the magnitude of the correction (P<.05). The induction of spherical aberration negatively correlated with the increase in BSCVA (P<.05). There were no significant differences between normal eyes and amblyopic eyes with respect to postoperative improvement in BSCVA (P>.05).
Decreased preoperative BSCVA, lower total spherical aberration induction, and preoperative mixed astigmatism and high myopia correlate with an increase in BSCVA after LASIK.
研究与准分子激光原位角膜磨镶术（LASIK）后最佳矫正视力（BSCVA）提高相关的因素。
这是一项针对480例接受LASIK治疗近视、远视和混合散光患者的850只眼的非随机前瞻性临床试验。术前平均等效球镜度为-3.75±4.82屈光度（D）（范围：-13.88至6.00 D）。在该人群中，43例患者的72只眼（包括22只弱视眼）在LASIK术后6个月时BSCVA有所提高。所有患者均使用NAVEX平台进行LASIK手术。对这些眼睛进行分析，以评估与BSCVA提高相关的因素。分析术前和术后的BSCVA、屈光、瞳孔直径、角膜地形图、非球面性（Q值）、总像差和高阶波前像差。所有波前像差均使用NIDEK光学路径差扫描像差仪（OPD-Scan）在术前和术后6个月进行测量。
术后，平均球镜度为-0.44±1.30 D（范围：-4.50至+2.50 D）。BSCVA平均提高0.15±0.09 logMAR。观察到BSCVA的提高与术前BSCVA之间存在统计学显著的负相关（P<0.01）。与中度近视（P<0.05）和远视眼（P<0.001）相比，混合散光和高度近视眼在LASIK术后更有可能提高BSCVA。在近视患者中，BSCVA的改善程度与矫正量相关（P<0.05）。球差的诱导与BSCVA的提高呈负相关（P<0.05）。正常眼和弱视眼在术后BSCVA改善方面无显著差异（P>0.05）。
术前BSCVA降低、总球差诱导降低以及术前混合散光和高度近视与LASIK术后BSCVA的提高相关。
