Andren-Sandberg A, Ahrén B, Tranberg K G, Bengmark S
Department of Surgery, Lund University, Sweden.
Int J Pancreatol. 1991 Summer;9:145-51. doi: 10.1007/BF02925590.
The development at a university hospital of radical surgery for exocrine pancreatic cancer has been studied for the time period 1958-1989. It was found that the number of operations per year increased gradually, being 6.6/year during the last 5 years, giving a resection rate of 15%. The resection rate did not change during the studied time period. The size, grade of differentiation, or stage of tumor did not change. There was no significant tendency toward decreasing operation time and blood loss, although a technically more complicated operation has been done in the last 30 cases (change from total to subtotal duodenopancreatectomy). The hospital mortality rate decreased from 33 to 3%. The rate and severity of post-operative complications also strongly decreased. For the last 30 cases, there was also a prolonged long-term survival. We conclude that the total management of patients radically operated on for exocrine pancreatic cancer is today much better than it was a decade or two ago.
对一所大学医院1958年至1989年期间外分泌型胰腺癌根治性手术的发展情况进行了研究。结果发现，每年的手术数量逐渐增加，过去5年中为每年6.6例，切除率为15%。在研究期间，切除率没有变化。肿瘤的大小、分化程度或分期也没有变化。尽管在最后30例手术中采用了技术上更复杂的手术方式（从全十二指肠胰腺切除术改为次全十二指肠胰腺切除术），但手术时间和失血量并没有明显的减少趋势。医院死亡率从33%降至3%。术后并发症的发生率和严重程度也大幅下降。在最后30例病例中，长期生存率也有所延长。我们得出结论，如今对外分泌型胰腺癌接受根治性手术患者的整体管理比一二十年前要好得多。
